Introduction Tetraphenylporphyrin will be synthesized and metallated with silver acetate. After purification and NMR and UV-visible spectra was taking for the original porphyrin synthesized and the silver porphyrin. From this data obtained we will talk about silver’s effect on porphyrin. Theory Porphyrin is important to study because it plays keys roles in biological process; they are responsible for giving plants and blood their colors green and red respectively. Porphyrins have the iron chelate
Premium Chemistry Protein Molecule
DISCIPLINE OF PHARMACEUTICAL CHEMISTRY DRUG DESIGN AND DISCOVERY BY: xxxxxxx Introduction A drug is a substance that we used mostly in our daily lives. It is a chemical substance with physiological effects when ingested or introduced into our bodies. The response produce can either be beneficial or harmful. Toxins and poisons can be classified as drugs. This report the term ‘drug’ is for medicinal or pharmaceutical purposes. Drugs used to prevent or treat diseases. Drug design
Premium Chemistry Nuclear magnetic resonance Drug discovery
General Features of Oxidative Additions Oxidative addition reactions usually involve a coordinatively unsaturated 16-electron metal complex or five-coordinate 18-electron species‚ and take the general from: [pic] If the A and B ligands in the product are considered to be formally –1‚ then the metal center has increased its oxidation state by +2‚ and this is the origin of the name oxidative addition. Oxidative reaction can occur when a metal complex
Premium Alkene Organic reaction Functional groups
mixture of a neutral (ester‚ alcohol‚ ketone‚ aldehyde or ether) and an acidic compound (phenol or carboxylic acid) or a neutral and a basic compound (amine)‚ and to identify the unknown mixture by physical (M.P. or B.P.) and spectroscopic methods (NMR‚ IR and MS). Method The mixture (sample number: 27) was dissolved in 200 mL of CH2Cl2 and then extracted with 10% NaOH. The acid was removed by adding 3 x 50 mL of 10% NaOH. The neutral component in CH2Cl2 solution was set aside. The NaOH extracts
Premium Chemistry Molecule Chemical compound
ca. 3500 2260-2240 1600-1500 and 1400-1300 m m m m m s -OH‚ -NH CHEMICAL SHIFTS CHCl3 H H 1H-NMR 12 O R C OH 11 R 10 O C H 9 R 8 7 6 H 5 CH2F 4 3 CH2Ar CH2NR2 CH2S 2 1 C H C C C-CH2-C C 0! TMS H CH2Cl CH2Br CH2I CHEMICAL SHIFTS CH2O C C-H C O CH2 C-CH3 carbonyl aromatic; alkene CH2NO2 alkane 13C-NMR CH2 200 150 alkyne 100 50 C-O‚N‚X 0! TMS CHM 2211-U01 SAMPLE EXAM I‚ Page 3 MULTIPLE
Premium Carboxylic acid Alcohol Infrared spectroscopy
was recrystallized in aqueous EtOH (70%) to give pure products. Selected spectra: 3 -(2′-benzothiazolo)-2‚3-dihydro-2-(4-chlorophenyl)-quinazolin-4(1H)-ones ( Table 1 Entry 1): m.p 229-239 oC; IR (KBr): υ = 3335‚ 1634‚ 1502‚ 1406‚ 1254‚ 740cm-1; 1H NMR (400 MHz‚ DMSO-d6): δ = 6. 81 (t‚ 1H‚ J = 8 Hz)‚ 6.85 (d‚ 1H‚ J = 8 Hz)‚ 7.30 (d‚ 2H‚ J = 8 Hz)‚ 7.36 (t‚ 3H‚ J = 8 Hz)‚
Premium Chemistry Ethanol Acetic acid
time-resolved attenuated total reflectio Fouriertransform infrared spectroscopy. Proc. Natl. Acad. Sci. USA 96‚ 5498– 5503. 8. Jeng‚ M.-F.‚ and Dyson‚ H. J. (1996) Direct measurement of the aspartic acid 26 pK a for reduced Escherichia coli thioredoxin by 13 C NMR. Biochemistry 35‚ 1–6. 9. Qin‚ J.‚ Clore‚ G. M.‚ and Gronenborn‚ A. M. (1997) Ionization equilibria for side-chain carboxyl groups in oxidized and reduced human thioredoxin and in the complex with its target peptide from the transcription factor NFκB
Premium Hydrogen bond Amino acid Hydrogen
Abstract: This experiment synthesized H-Gly-Phe-OH dipeptide using “Fmoc chemistry”. The first part of experiment was the synthesis of L-phenylalanine methyl ester hydrochloride. The methyl ester can be synthesised by reaction of thionyl chloride‚ SOCl2 and dry methanol with L-phenylalanine under reflux condition. The peptide bond was formed later in the experiment‚ where HBTU‚ DiPEA and a solution of Fmoc-Gly-OH in DMF were added to a solution of L-phenylalanine methyl ester hydrochloride in DMF
Premium Chemistry Chemical reaction Oxygen
Chapter 17—Alcohols and Phenols SHORT ANSWER Drawing Instructions: Draw structures corresponding to each of the given names. 1. Draw: cis-4-tert-butylcyclohexanol ANS: 2. Draw: 3-methyl-2-buten-1-ol ANS: 3. Draw: 2-phenyl-2-propanol ANS: 4. Draw: glycerol ANS: 5. Draw: 2‚ 4‚ 6-trinitrophenol ANS: IUPAC Naming Instructions: Provide proper IUPAC names. 6. Name: ANS: (E)-2-ethylbut-2-en-1-ol 7. Name: HOCH2CH2OH ANS:
Premium Alcohol Acid
with Thin Layer Chromatography and one using NMR spectrometry. We will do this by making 2‚ 4 a DNPH derivative and checking the melting points. Theory: By Using specific methods of compounds detection‚ we can match an unknown compound with a known compound because similar compounds will display similar characteristics. In this experiment‚ identifications of the unknown ketone was accomplished using thin layer chromatography‚ melting point‚ and NMR spectrometry. Thin layer chromatography is
Premium Nuclear magnetic resonance