Drug Design
DISCIPLINE OF PHARMACEUTICAL CHEMISTRY DRUG DESIGN AND DISCOVERY BY: xxxxxxx
Introduction A drug is a substance that we used mostly in our daily lives. It is a chemical substance with physiological effects when ingested or introduced into our bodies. The response produce can either be beneficial or harmful. Toxins and poisons can be classified as drugs. This report the term ‘drug’ is for medicinal or pharmaceutical purposes. Drugs used to prevent or treat diseases. Drug design also known as rational drug design is the creative process of discovering or finding a new drug based on the knowledge of a biological target. Modern drug discovery involves the identification of screening hits, medicinal chemistry and optimization of those hits to increase the affinity, selectivity (to reduce the potential of side effects), efficacy/potency, metabolic stability (to increase the half-life), and oral bioavailability. Once a compound that fulfils all of these requirements has been identified, it will begin the process of drug development prior to clinical trials. One or more of these steps may, but not necessarily, involve computer-aided drug design. Humanity has been has been consuming and experimenting with drug substance for centuries. This dates back in the early days of human civilization when drugs were not only used for their therapeutic properties but they were also used in association with religion and spiritual healing. This all changed when chemistry reached a high level of maturity principles and methods started to be applied and drug researches were performed this then gave rise to drug discovery and design. In the 1800s drug design and discovery started following scientific techniques and around the 1810 essential foundations of chemical theory had been laid. Drugs are mostly discovered by accident or by “luck”. Drug discovery deals with the synthesis and design of the drug. It is not the drug itself that that gets discovered but the
Introduction A drug is a substance that we used mostly in our daily lives. It is a chemical substance with physiological effects when ingested or introduced into our bodies. The response produce can either be beneficial or harmful. Toxins and poisons can be classified as drugs. This report the term ‘drug’ is for medicinal or pharmaceutical purposes. Drugs used to prevent or treat diseases. Drug design also known as rational drug design is the creative process of discovering or finding a new drug based on the knowledge of a biological target. Modern drug discovery involves the identification of screening hits, medicinal chemistry and optimization of those hits to increase the affinity, selectivity (to reduce the potential of side effects), efficacy/potency, metabolic stability (to increase the half-life), and oral bioavailability. Once a compound that fulfils all of these requirements has been identified, it will begin the process of drug development prior to clinical trials. One or more of these steps may, but not necessarily, involve computer-aided drug design. Humanity has been has been consuming and experimenting with drug substance for centuries. This dates back in the early days of human civilization when drugs were not only used for their therapeutic properties but they were also used in association with religion and spiritual healing. This all changed when chemistry reached a high level of maturity principles and methods started to be applied and drug researches were performed this then gave rise to drug discovery and design. In the 1800s drug design and discovery started following scientific techniques and around the 1810 essential foundations of chemical theory had been laid. Drugs are mostly discovered by accident or by “luck”. Drug discovery deals with the synthesis and design of the drug. It is not the drug itself that that gets discovered but the