Aspirin is prepared by the esterification of salicylic acid with acetic anhydride under acidic conditions. The phenol group in salicylic acid is replaced by a carboxyl group through electrophilic substitution. The mechanism for the reaction can be summarized as follows: Figure 11.4. Mechanism for the reaction of salicylic acid and acetic anhydride to form acetylsalicylic acid (aspirin) In this experiment‚ 85% phosphoric acid (H3PO4)‚ a strong acid‚ is used as a catalyst to speed up the reaction
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control wilt disease complex in abaca caused by Fusarium oxysporum f. sp. cubense (FOC) and Ralstonia solanacearum. Suspected biological elicitors (Fomes and Xanthomonas oryzae pv. oryzae or Xoo) and known chemical elicitors (Asprin or Acetyl Salicylic acid and Boost) were sprayed to the abaca tissue cultured seedlings at 15 days interval together with water and Nordox (fungicide with bactericidal activity) as checks. The sprayed seedlings were challenged by simultaneous inoculation with FOC and
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Experiment 4: Heating Under Reflux- Synthesis of Salicylic Acid from Wintergreen Oil Precious Ahmed ID# 6463614 Section 07‚ Friday afternoon Lab experiment performed on: Friday‚ January 19‚ 2013 Lab report submitted on: Friday‚ January 24‚ 2013 Introduction Before the synthetic aspirin of today‚ salicylic acid‚ which is the important ingredient found in aspirin‚ was extracted naturally from methyl salicylate found in Wintergreen oil‚ which could be found in certain plants. The purpose
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Experiment Four: Organic Synthesis of Aspirin Abstract The purpose of this experiment is to synthesize a common organic product called acetylsalicylic acid (aspirin)‚ and to become familiar with the optimum conditions needed for successful yields. Aspirin is produced from an acid catalyzed reaction between salicylic acid with acetic anhydride. The crystalline aspirin is synthesized and purified by recrystallization‚ although there is not a hundred percent yield due to sources of error. Introduction
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esterification by reacting salicylic acid with acetic anhydride with the presence of dehydrating agent‚ conc. sulphuric acid‚ to speed up the reaction. Having obtained the crude aspirin which was still impure‚ recrystallisation was conducted to remove the impurities. The aspirin harvested at the end of the experiment was 1.19g with the percentage yield of 37.8%. The melting point observed from the product ranged from 133°C to 137°C. Introduction Acetylsalicylic acid or commonly known as aspirin
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Synthesis of Aspirin (Acetylsalicylic Acid) Abstract: This experiment is about the synthesis of aspirin under laboratory conditions. Aspirin is prepared by reacting salicylic acid and acetic anhydride; in the presence of sulfuric acid. After fully dissolving the salicylic acid with acetic anhydride‚ the solution is cooled and cold water is then added. Once the crystals form they are then filtered and left to dry out. There mass is measured and recorded then the yield is calculated. Introduction:
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ethnicities. However‚ Acne Free contains a cleanser‚ toner‚ and moisturizer each have 2.5% benzoyl peroxide‚ and the Clean and Clear Advantage Acne Control Kit contains a cleanser with 10% benzoyl peroxide‚ moisturizer with 0.5% salicylic acid and a spot remover with 2% salicylic acid. Products within each kit contain different ingredients and are both made by different companies. Below are comparisons on how each product leaves the skin feeling‚ variation in cost‚ and a description of the
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etc. Synthesis of Aspirin and Methyl Salicylate. The two compounds we will be preparing‚ aspirin (acetylsalicylic acid) and oil of wintergreen (methyl salicylate)‚ are both organic esters. An ester is a compound that is formed when an acid (containing the COOH group) reacts with an alcohol (a compound containing an -OH group). O C R1 O H O + H O C R2 R1 O R2 + H O H acid alcohol ester water Here R1 and R 2 represent groups such as CH3 - or CH3 CH2 -. The reaction type shown
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(ACETYLSALICYLIC ACID) Aim: The aim of this experiment was to react salicylic acid with ethanoic anhydride to produce Aspirin. CH3CO)2O + HOC6H4COOH → CH3CO2C6H4CO2H + CH3COOH i Mass: 5g Volume: 7.5 cm3 Mass: 6.52g RMM: 138g/mol RMM: 180g/mol Moles: 5/138 = 0.0362 RMM: 102g/mol Moles: 0.0362 OBSERVATIONS – First‚ Ethanoic acid was added to the salicylic acid which resulted in a cloudy solution. When adding a few drops of concentrated sulfuric acid‚ which acted as
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Experiment #1: Synthesis of Salicylic Acid From Wintergreen Oil By: Asad Razzaq TA: Date: 18/01/2015 222/Lab Section 8 Introduction Salicylic acid‚ used in production of substances used worldwide such as commonly used analgesic drug aspirin(cite)‚ can be obtained from natural resources such as wintergreen oil or can be synthesized. Through a series of chemical reactions with cheap raw materials beginning with beginning with methyl salicylate and‚ it is a cheaper and more
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