presence of acetic anhydride‚ acetylsalicylic acid (aspirin or ASA) is formed. Correspondingly‚ an excess of methanol will form methyl salicylate‚ which is also an analgesic. In this experiment‚ we shall use the former reaction to prepare aspirin. Salicylic acid will not react significantly with acetic acid to produce aspirin. Acetic acid anhydride‚ however‚ is more reactive than acetic acid because the acetoxy group (-O2CCH3) is a much better leaving group than the OH- of acetic acid.
Free Aspirin Acetic acid Carboxylic acid
ice bath and a fluted filter paper while others were tasked to weigh the filter papers in advance so that the experiment will flow smoothly. The formation of crude acetanilide was due to the acetylation of aniline and acetic anhydride. The recrystallizing solvent dissolved the acetic acetanilide and was heated in a water bath. Crystals started to form after cooling the solutions in an ice bath. Pure acetanilide was the product after the second crystrallization which was obtained by finally removing
Premium Solubility Solvent Acetic acid
of Santo Tomas Manila‚ Philippines ABSTRACT This experiment involved three steps: synthesis of aspirin‚ isolation and purification‚ and the estimation of purity of the final product. The synthesis involved the reaction of salicylic acid and acetic anhydride in the presence of a catalyst‚ phosphoric acid‚ H3PO4. When the aspirin was prepared‚ it was isolated and filtered. The percentage yield of the synthesis was calculated to be 78.42%. The experimental melting point range of aspirin was determined
Premium Aspirin Acetic acid Acetic anhydride
Preparation of Acetylsalicylic Acid Abstract Acetylsalicylic acid was prepared using salicylic acid and acetic anhydride. As a result‚ a white‚ powdery substance was formed (0.1931g‚ percent yield 91.30%) and was defined by melting point (124.5 – 134.5°C) and observation of color change with ferric chloride. Introduction Acetylsalicylic acid (aspirin) is one of the most popular analgesic drugs on the market today. It also acts as an antipyretic and anti-inflammatory drug. Salicylic acid itself
Free Aspirin Acetic acid Paracetamol
Preparation and Recrystallisation of Aspirin Contents Page Synopsis iii 1 Introduction 1 1.1 Objective 1 1.2 Background 1 2 Theory 1 3 Procedure 2 3.1 Materials 2 3.2 Preparation 2 3.3 Recrystallisation 3 3.4 Determination of Melting Point 3 4 Results and Calculation 4 4.1 Mass 4 4.2 Percent yield 4 4.3 Melting Point 4 4.4 Appearance 4 5 Discussion 5
Premium Acetic anhydride Acetic acid Aspirin
Molar Mass: 138.12 g/mol Melting Point: 1590C Boiling Point: 2110C Density: 1.44 g/cm3 Mildly irritating (pulmonary irritants). Harmful by inhalation‚ ingestion and through skin absorption. Acetic Anhydride Starting‚ Material‚ serves also as the solvent colorless liquid with a smell of acetic acid Molar Mass: 102.09 g/mol Melting Point: -73.1 0C Boiling Point: 139.8 0C Density: 1.082g/cm3 Corrosive Flammable and Lachrymator which makes eyes teary. It is poisonous and will cause
Free Aspirin Acetic acid Acetic anhydride
acid‚ was synthesized from salicylic acid and acetic anhydride. In the reaction the hydroxyl group on the benzene ring in salicylic acid reacted with acetic anhydride to form an ester functional group. This method of forming acetylsalicylic acid is an esterification reaction. Since this esterification reaction is not spontaneous‚ sulfuric acid was used as a catalyst to initiate the reaction. After the reaction was complete some unreacted acetic anhydride and salicylic acid was still be present in the
Premium Aspirin Acetic acid Salicylic acid
that on August 10‚ 1897 Felix Hoffmann‚ a German chemist who obtained his PhD with Adolf von Baeyer (see below) and working at "Farbenfabriken vorm. Friedr. Bayer & Co." made a discovery of historic significance. By acetylating salicylic acid with acetic acid‚ he succeeded in creating acetylsalicylic acid (ASA) in a chemically pure and stable form. Esterifying the salicylic acid to aspirin reduces the irritation of the stomach lining. The company developed a cost-effective production process that
Free Aspirin Acetic acid Sodium hydroxide
Acetylsalicylic Acid Introduction: The purpose of this experiment is to create and isolate pure acetylsalicylic acid from the substances salicylic acid and acetic anhydride. Then one will find the melting point to determine purity. Procedure: Make a hot bath. Weigh some salicylic acid and place in conical vial. Add .480mL of acetic anhydride and a drop of concentrated phosphoric acid. Drop in a magnetic spin vane and attach air condenser to vial. Partially submerge it in hot water. Stir with
Free Aspirin Carboxylic acid Acetic anhydride
This yields sodium salicylate which will be acidified in methanol (CH3OH) which will remove the sodium bonded to the oxygen‚ and switch it to a hydrogen atom bonded to the oxygen‚ making an alcohol group. This new product is salicylic acid. Acetic anhydride is added to the salicylic acid to add an acetyl group to carbon 2 which will create acetylsalicylic acid
Premium Aspirin Salicylic acid Acetic acid