Abstract: This experiment is to demonstrate the preparation of paracetamol and its properties. Reflux and filtration of 4-aminophenol and acetic anhydride formed the crude sample. Further analysis of dry white crystals were used to give quantitative measurements and a percentage yield of 46% was obtained. The overall conclusion is that the acetic anhydride reacted with the –NH2 group. Materials and Methods: 1. We weighed out (on a top-pan balance) 4-aminophenol (about 11.0g) in a weighing
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Synthesis of Acetanilide Reaction O NH2 + H3C C O O C CH3 O N C CH3 H + H3C O C OH Aniline Acetic anhydride Acetanilide Acetic acid Purpose: Acetanilide is a useful precursor to many pharmaceuticals such as acetaminophen and penicillin. Experimental Procedure. (Estimated time: 1.5 h.) Unless otherwise noted‚ all manipulations should be done in the chemical fume hood. Place 100 µL of aniline into a tared 10 X 75-mm test tube (standing in a small beaker or Erlenmeyer flask). Now add
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Purpose: To synthesize acetylsalicylic acid on a microscale basis. Equipment / Materials: |salicylic acid |filter paper | | |acetic anhydride |hot water | | |conc. phosphoric acid |ice
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experiments. Expt.1. Acetylation of α-D-glucopyranose Add slowly 2.5 g (0.014 mol) of powdered D-glucose in small portions (roughly in 7-10 portions and 5 min for each addition) into a preheated solution of ZnCl2 (0.5 g anhydrous ZnCl2 in 12.5 ml acetic anhydride‚ this will be provided by lab. technician) in a 50 ml pear shape flask (heat in water bath for 10-15 min before addition start). The flask is attached with an air condenser. Swirl the mixture gently during the addition to control the vigorous
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Sypnopsis In this experiment‚ acetylsalicylic acid was synthesized from the acidification of salicylic acid and acetic anhydride. The objective was to convert a specific amount of salicylic acid into the same amount of aspirin that was high in purity. Furthermore‚ the other objectives were to enable students to conduct the synthesis of aspirin‚ reinforce skills or recrystallisation and the technique of melting point determination. The amount of each compound should be the same because there is
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Y1315 Lab supporting staffs: YK Au / Kan Chan/Arnold Demonstrators: Dr. Samuel Lee‚ Alston Lee‚ Fu Wai Chung‚ Guo Shuai‚ Yuen On Ying‚ Sep 16 Tue Acetylation of α-D-glucopyranose (Expt 1) Sep 23 Tue Cis-1‚2‚3‚6-tetrahydro-4‚5-dimethylphthalic anhydride (Diels-alder reaction) (Expt 2) Sep 30 Tue Photochemical Reaction and Acid-catalyzed Rearrangement: Cycloaddition reactions (Expt.3‚ Part A) and Michael Addition (Expt 4‚ part A) Oct 7 Tue Michael Addition (Expt 4‚ part B) Oct 14 Tue Photochemical
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CHOONG SHING YI CHOONG SHING YI Preparation and Recrystallization of Aspirin Preparation and Recrystallization of Aspirin Date of the experiment: 9 May 2013 Date of submission: 23 May 2012 Date of the experiment: 9 May 2013 Date of submission: 23 May 2012 Synopsis 1. General Objective: To familiarize with the preparation of some simple organic compound and purify the compound by recrystallization. Specific Objective: The experiment is carried
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mucous membranes of the mouth and stomach.Then‚ in 1893 a chemist named Felix Hoffman synthesized acetylsalicylic acid. The purpose of this experiment is to synthesize aspirin from salicylic acid and acetic anhydride. To filter and air dry to find the actual
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point of the aspirin sample‚ which will in turn indicate the purity of the sample. The last is conducting a colorimetric analysis on the aspirin sample. The educational goals of this lab are to find the structural formulas for salicylic acid‚ acetic anhydride‚ and aspirin and to use these structural formulas to construct a reaction equation by describing the synthesis of aspirin. In addition‚ you have to be able to use your percent purity calculations to determine the percent yield of your synthesis
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filtering the chilled reaction solution. Purification is essential to remove any unreacted salicylic acid and acetic anhydride as well as the acetic acid product and phosphoric acid. Acetic anhydride is caused to decompose by the addition of water once the formation of aspirin is complete. C4H6O3 (Acetic anhydride) + H2O (Water) -------------------------> 2C2H4O2 (Acetic Acid) The acetic acid and phosphoric acid are water soluble and it is removed by washing the aspirin with chilled water
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