Kuroda et al. Skeletal Muscle 2013‚ 3:5 http://www.skeletalmusclejournal.com/content/3/1/5 Skeletal Muscle Open Access RESEARCH Canonical Wnt signaling induces BMP-4 to specify slow myofibrogenesis of fetal myoblasts Kazuki Kuroda1‚4‚ Shihuan Kuang1‚2‚ Makoto M Taketo3 and Michael A Rudnicki1* Abstract Background: The Wnts are secreted proteins that play important roles in skeletal myogenesis‚ muscle fiber type diversification‚ neuromuscular junction formation and muscle stem cell function
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Biochemistry of Muscle Contraction Fred P. Guillergan M.D.‚ FPCP Outline histology and biochemistry of muscles (Striated & smooth) – Myosin – Actin‚ Tropomyosin‚ Troponin – Accessory proteins of muscles Biochemical events in muscle contraction Calcium‚ Ca2+-binding proteins and Ca2+ channels in muscle contraction Biochemistry of Cardiac & Smooth muscle contraction Energetics of muscle contraction ☻Able to understand the normal anatomy and physiology of different types of muscles ☻ Provide
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The Aging Musculoskeletal System The human musculoskeletal system is the organ system that gives humans the ability to physically move‚ by using the muscles and skeletal system. It consists of the muscular system and the human skeleton. Bones are connected to each other at the joints by ligaments or cartilage and skeletal muscle is attached to bones‚ usually by tendons. Bones mass or density is lost as people age‚ especially in women after menopause. The bone loses calcium and other minerals. Bone
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1. Discuss the relationship between distribution of muscle fiber type and performance. How might exercise training modify or change a person’s fiber-type distribution? Skeletal muscles contain multiple fiber types that are distinguished by their different myosin ATPase speed‚ and the development of their SR. The two main fiber types are type I and type II fibers. Type II fibers have a faster ATPase and a more developed SR than type I fibers. Type II fibers are also part of a larger motor unit‚
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initiate contraction‚ given the affinity of troponin to calcium. As troponin attaches to calcium‚ it produces a movement of the tropomyosin molecule that frees up the actin site so that the charged cross-bridge can contact the site resulting in the liberation of energy from the adenosine triphosphate (ATP) molecule. Nerve impulses are sent from the motor cortex of the brain through the spinal cord. The musculocutaneous nerve continues the wave of axon depolarization to individual muscle fibers via
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Nutrition A Muscle Contraction Muscle Contraction is part of an organ in the body that is tensive. It may have a process of tensions that may be developed with muscle tissues. Contraction can be a meaning of shortening or long. Muscle Contraction can also produce a muscle cell that is for movement of the body. Myosin and Actin is an interaction protein to Muscle Contraction‚ it can be changed by shape but not by volume. Skeletal Muscle contraction is produce by heat. The muscles may receive signal
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The series of events prompting muscle contraction is started some place in the central nervous system‚ either as willful action from the brain or as reflex action from the spinal cord. Beginning with depolarization at the neuromuscular junction‚ the depolarizing impulse discharges acetylcholine from the nerve ending. Which then diffuses over the neuromuscular junction (a chemical synapse formed by the contact between a motor neuron and a muscle fiber). At the motor end plate‚ the acetylcholine joins
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an involuntary muscle‚ found solely in the walls of the heart‚ as well as in the walls of the blood vessels. This sort of muscle has similarities with the skeletal muscles‚ because it is striated. Furthermore‚ it has slight similarities to the smooth muscles‚ because its contractions are not under conscious control. On the other hand this type of muscle is highly specialised. It is under the control of the autonomic nervous system‚ however‚ even without nervous imput contractions can occur due to
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more than 600 muscles in our bodies. They pump blood throughout your body‚ and help you lift heavy things like backpacks‚ and textbooks. You could control some of your muscles‚ while others like your heart‚ have their own jobs without us thinking at all. Muscles are all made up of same material. A type of tissue like the material in a rubber band. Thousands or tens of thousands of small fibers make up all or each muscle in our body. There are different muscles‚ fibers‚ and contractions. Three
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Exercise 8 Simple Muscle Contraction • 3 Phases AB - lag phase or latent phase - (shortest) 0.00sec‚ usually less than 0.01sec - brief period that exists between the application of the stimulus and the start of contraction BC - contraction‚ 0.05sec - peak - shortening of the muscle occur CD - relaxation period‚ 0.05 sec - Occurs when Ca+ is transported back in the sarcoplasmic reticulum Single muscle contraction= 100vib/sec (tuning fork)= 0.10 sec 10vib (result) Neuromuscular junction - formed when
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