McCance and Huether (2014) defined Multiple Organ Dysfunction Syndrome (MODS) as a continuum of physiologic derangements characterized by dynamic alterations of two or more organs’ function in a state of critical illness. As the name indicates‚ MODS is a syndrome and not a specific health condition since it involves various organs. In the past‚ “multiple organ failure” was the term used to describe the condition until it became apparent that it was misleading since normal physiological function of
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There are broad ranges of Calpain Inhibitors in the body that are classified under the family of cytosolic calcium-regulated cysteine. The protein falls into the family of proteolysis enzymes and calcium-dependent and they are expressed ubiquitously in mammals amongst many other organisms. The elements roles include regulating various forms of cellular processes in the body. In addition‚ there is Calpain submembranous and cytoskeletal proteins‚ which contribute greatly to muscle protein degradation
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actively protesting against GM foods for some time‚ and recent controversial studies have brought the issue of genetic engineering to the forefront of the public consciousness. Among the reports‚ several have shown the relationship between GMO cytotoxicity as well as the teratogenic potential in mammals. Specifically the toxins glyphosate‚ and Bacillus thuringiensis (Bt) present a combined area of concern as these herbicide resins and insecticidal toxins are present in Roundup-tolerant GM plants
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Vitamin D Levels and Multiple Sclerosis Alicia R. Turner ITT TECH Institute Vitamin D Levels and Multiple Sclerosis Multiple Sclerosis is an auto-immune deficient disease with no known cure to date. Multiple Sclerosis is damage done to the fatty sheath‚ myelin‚ which insulates the nerve fibers in the brain. Multiple Sclerosis symptoms or flare-ups‚ as they are often referred‚ may include seizures‚ double vision‚ numbness‚ muscle control‚ difficulty with speech and ability to
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TITILE OF THE PROJECT pH SENSITIVE CHITOSAN DERIVATIVE POLYMERICS NANOPARTICLES AS DRUG CARRIER IN TARGETING COLON CANCER CELLS INTRODUCTION: Cancers area group of diseases characterized by uncontrolled growth of abnormal cells in tissues and its leading cause of death. To date‚ cancer caused 7.6 million deaths (around 13% of all deaths) around the world and this will projected to continue to rise to over 13.1 million deaths in 2030. Among this colon cancer arises when this uncontrolled cell
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Background-done-I-10 Description-done-P-10 Proposed strategy-P/I-20 a Phase II study can be performed-Title Rationale-P/I-20 Trial Outline-P/I-30 Background Bortezomib‚ chemically a dipeptidyl boronic acid from the amino acids leucine and phenyl alanine‚ is a proteosome inhibitor. It causes accumulation of the growth inhibitory molecules p21 and p27 subsequently leading to cell arrest and cell death. • Irinotecan is a prodrug‚ whose active metabolite inhibits Topoisomerise 1 leading
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Nanocellulose Nanotechnology is a promising area that greatly contributes to a sustainable utilization in various training‚ research and developmental applications (Salah‚ 2013). However‚ there are few challenges that has to be overcome to promote its multifunction in various industrial application (Salajkova et al.‚ 2013). The challenges are such as: i. The homogeneous dispersion of the nanomaterial in a small scale. ii. Development of low cost materials. Over the years‚ nanocellulose has been widely
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The term oxidative stress has been often used to indicate the outcome of oxidative damage to biologically relevant macromolecules such as: nucleic acids‚ proteins‚ lipids and carbohydrates. This occurs when oxidative stress-related molecules‚ produced in the extracellular environment or within the cell exceed cellular antioxidant defenses (Cadenas‚ 1989). Molecular oxygen can easily accept unpaired electrons giving rise to a group of partially reduced species‚ generally termed ROS. The ROS include:
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JPRHC Review Article REVIEW ON PHYTOCHEMISTRY AND PHARMACOLOGICAL ASPECTS OF EUPHORBIA HIRTA LINN. SANDEEP B. PATIL*‚ MRS. NILOFAR S. NAIKWADE‚ CHANDRAKANT S. MAGDUM For author affiliations‚ see end of text This paper is available online at www.jprhc.com ABSTRACT: Medicinal herbs are the local heritage with global importance. Medicinal herbs have curative properties due to presence of various complex chemical substance of different composition‚ which are found as secondary plant metabolites in
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The antibacterial activity of the green synthesized silver nanoparticles from aqueous extract of Gum of fresh Coconut was tested by the disc diffusion method against an antibiotic‚ ampicillin(1µg/µl) as a standard drug. The antibiotic resistant bacteria viz.‚ Staphylococcus aureus‚ Bacillus subtilus‚ Escherichia coli and Klebsiella pneumonia were used for the measurement of antibacterial activity‚ and the plates were incubated at 370C overnight to know the zone of inhibition. 2.2. Cell Culture and
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