Abstract In the asymmetric synthesis of (S)-Ibuprofen‚ the compound is synthesized in nonracemic form directly from an achiral precursor. First‚ racemic ibuprofen was converted to aN achiral ketene via the acid chloride by adding thionyl chloride followed by triethylamine. Then‚ ketene was reacted with a chiral and nonracemic (S)-ethyl lactate produces a mixture of diasteromeric esters of ibuprofen derivatives where (S) configuration is predominantly. Finally‚ hydrolysis of the ester then provides
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ELECTRONEGATIVITY This page explains what electronegativity is‚ and how and why it varies around the Periodic Table. It looks at the way that electronegativity differences affect bond type and explains what is meant by polar bonds and polar molecules. If you are interested in electronegativity in an organic chemistry context‚ you will find a link at the bottom of this page. What is electronegativity Definition Electronegativity is a measure of the tendency of an atom to attract a bonding pair
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1 CHM 1321-C Final Exam (prof. S. Gambarotta) Your Name: ___________________ April 12– 2013 Student #: ______________ 1. Solution key will be posted today on the web to day. 2. You must respond correctly to the first 41 exercises (1 mark each) to get the full mark. 3. There are 3 bonus questions at the end (4 mark each). In case of correct answers‚ each will add 4 marks to whatever you scored from the non-bonus questions. 4. Deliver the entire booklet 2 1) How many π bonds are present in
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29) The structural formulas are given for these cis or trans alkenes. (a) trans-1‚2-dichloropropane (b) cis-2-pentene (c) cis-3-hexene (d) trans-2-hexene Write the structural formula for: (a) cis-1‚2-dichloropropene (b) trans-2-pentene (c) trans-3-hexene (d) cis-2-hexene 30) In each case‚ tell whether cis and trans exist. If they do‚ write the structural formulas for two isomers and label each cis or trans‚ (a) Br2CH2 : No (b) CH3CH2CH=CHCH2CH3: Yes (c) CH3CH=CHCH3:
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Liceo de Cagayan University COLLEGE OF MEDICAL LABORATORY SCIENCE Rodolfo N. Pelaez Boulevard‚ Kauswagan‚ Cagayan de Oro City An Organic Chemistry Project About Saturated and Unsaturated Fats in Vegetable Oils‚ Margarines‚ and Peanut Butters Submitted by : Zedrik O. Ortiz Submitted to : Dr. Luzviminda H. Saliga DEFINITION OF TERMS Saturated fat is a fatty acid that consists of triglycerides containing only saturated fatty acids. Saturated fatty acids have no double bonds between the
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β-unsaturated ketone such as the product in this experiment: trans-p-anisalacetophenone1. The major product of an aldol condensation is usually observed as a trans product as it provides less steric hindrance due to the substituents on each side of the alkene being placed farther apart1. 2‚4-dinitrophenylhydrazine is also used in this experiment to indicate the presence of a ketone. When hydrazine is reacted with a ketone in acidic conditions it produces 2‚4-dinitrophenylhydrazone which is a bright red
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November 15‚ 2007 Synthesis of 1-Bromobutane Introduction: The purpose of this experiment is to synthesize 1-bromobutane from 1-butanol and sodium bromide. In order for this reaction to reach completion there are four major operations that need to be performed. The four major operations include refluxing‚ simple distillation‚ separation‚ and drying. To begin‚ in order for the compounds to react they will be dissolved in water and sulfuric acid will be added. The addition of sulfuric acid will
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CARIBBEAN EXAMINATIONS COUNCIL Caribbean Advanced Proficiency Examination CAPE ® CHEMISTRY SYLLABUS Unit 1 - effective for examinations from May/June 2007 Unit 2 - effective for examinations from May/June 2008 CXC A11/U2/06 Published by the Caribbean Examinations Council All rights reserved. No part of this publication may be reproduced‚ stored in a retrieval system‚ or transmitted in any form‚ or by any means electronic‚ photocopying‚ recording or otherwise without prior permission
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preventing the formation of prostaglandin. Prostaglandin is the active agent that is responsible for the sensitisation at the nerve endings. It can be administered orally‚ rectally or by intravenous route. (6) Benzene ring Carboxylic acid Ester Alkane Aspirin has a pKa of 3.49 and a melting point of 138-140 degrees Celsius. Aspirin molecule’s are insoluble in water that is why it must be sold in a solid form‚ there are no liquid forms of aspirin available. Aspirin is ionised in the stomach. Aspirin
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mass spec can be seen in figure 6. According to the experimental IR spectroscopy for the E isomer of phenylcinnamic acid the peaks of the wavenumber were at 2952‚ 2518 1672 and 1426 cm-1. The peak at 2952 presents the double bond CH stretch for the alkene carbon. The peak at 2518 presents the carboxylic acid –OH peak. The peak at 1672 could present the carbonyl group. The aromatic ring peaks are around 1600 and 1426-1492. Different values could be seen for the z isomer. The wavenumbers for the IR
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