Quercetin Supplementation Essay
NFS301H1 – Assignment #1 - Annotated Bibliography
Research Question:
Does quercetin supplementation have an effect on exercise tolerance and maximal oxygen capacity (VO2max)? If so, are there differences seen between healthy active organisms as opposed to healthy sedentary organisms?
Annotated Bibliography:
This article aims to identify whether quercetin supplementation has the ability to increase peak oxygen uptake and exercise performance in moderately active and trained military participants. In a randomized, double-blinded study, Bingelan et al. compares the effects of quercetin supplement intake to placebo intake on VO2peak and physical performance, represented through four fitness tests. He randomly assigns participants in the quercetin …show more content…
More specifically, it looks at the effects of quercetin on exercise performance and how it may be beneficial in increasing endurance tolerance through both in vitro and in vivo studies. Davis et al. finds that quercetin is able to increase mitochondrial biogenesis as well as act as an antagonist to the adenosine A1 receptor, thus delaying fatigue and up-regulating dopamine release. The review article also discusses the positive effects of quercetin on reducing susceptibility of infections such as upper respiratory tract infection. The mechanisms he describes to reduce susceptibility includes: reducing effectiveness of target cells, blocking pathogen replication and up-regulating immune cell activity. The publication also describes benefits in quercetin intake and decreases in chronic disease, including: diabetes, neurodegeneration, cardiovascular disease and cancer. Often, inflammation and excess oxygen radicals aid in disease formation. This review shows quercetin has effects against oxidative damage as well as anti-inflammatory …show more content…
Furthermore, it explores and is able to show previous studies that either shows a positive or negative effect, confirming that the review was not biased. However, the publication fails to show much evidence from human clinical trials, making it difficult to fully apply in vitro research to understand effects of supplementation in humans. Overall, this review article is very relevant to the research question as it thoroughly summarizes significant in vitro and in vivo experimental studies in exercise capacity and provides results that show positive and negative effects of quercetin.
This primary research article assesses whether a 2 weeks of quercetin supplementation has the ability to increase mitochondrial biogenesis and exercise performance/ endurance in healthy sedentary males. In a randomized, double blinded, crossover study, Nieman et
Research Question:
Does quercetin supplementation have an effect on exercise tolerance and maximal oxygen capacity (VO2max)? If so, are there differences seen between healthy active organisms as opposed to healthy sedentary organisms?
Annotated Bibliography:
This article aims to identify whether quercetin supplementation has the ability to increase peak oxygen uptake and exercise performance in moderately active and trained military participants. In a randomized, double-blinded study, Bingelan et al. compares the effects of quercetin supplement intake to placebo intake on VO2peak and physical performance, represented through four fitness tests. He randomly assigns participants in the quercetin …show more content…
More specifically, it looks at the effects of quercetin on exercise performance and how it may be beneficial in increasing endurance tolerance through both in vitro and in vivo studies. Davis et al. finds that quercetin is able to increase mitochondrial biogenesis as well as act as an antagonist to the adenosine A1 receptor, thus delaying fatigue and up-regulating dopamine release. The review article also discusses the positive effects of quercetin on reducing susceptibility of infections such as upper respiratory tract infection. The mechanisms he describes to reduce susceptibility includes: reducing effectiveness of target cells, blocking pathogen replication and up-regulating immune cell activity. The publication also describes benefits in quercetin intake and decreases in chronic disease, including: diabetes, neurodegeneration, cardiovascular disease and cancer. Often, inflammation and excess oxygen radicals aid in disease formation. This review shows quercetin has effects against oxidative damage as well as anti-inflammatory …show more content…
Furthermore, it explores and is able to show previous studies that either shows a positive or negative effect, confirming that the review was not biased. However, the publication fails to show much evidence from human clinical trials, making it difficult to fully apply in vitro research to understand effects of supplementation in humans. Overall, this review article is very relevant to the research question as it thoroughly summarizes significant in vitro and in vivo experimental studies in exercise capacity and provides results that show positive and negative effects of quercetin.
This primary research article assesses whether a 2 weeks of quercetin supplementation has the ability to increase mitochondrial biogenesis and exercise performance/ endurance in healthy sedentary males. In a randomized, double blinded, crossover study, Nieman et