Irena Sendler created change by offering medicine and supplies. Irena brought food and medicine to the people in the Warsaw ghetto especially children. If it weren't for Irena bringing supplies then more people would've died. her and her friend Antori smuggled food and more medicine into the ghetto. The consequences were jail time. Or even death. The people in the ghetto got sick from hunger and/or from the unsanitary places they live in.
Secondly Irena related change by taking care of children. She took care of the children by helping them