In-Situ Gel Formulation Of Etodolac Case Study

________________________________________ Table 5.4: Floating Behavior of In-Situ Gel formulation of etodolac
S. NO. Formulation code Floating lag time (sec) floating time (hr)
1 P1 26 >12
2 P2 35 >12
3 P3 50 >12
4 P4 66 >12
5 P5 196 >12
6 P6 219 >12
7 P7 45 >12
8 P8 72 >12

Table 5.5: Gelling capacity of In-Situ Gel formulation of etodolac S.NO Formulation code Gelling capacity
1 P1 ++
2 P2 ++
3 P3 ++
4 P4 ++
5 …show more content…
6 P6 +++
7 P7 ++
8 P8 ++
*(++) Gelation immediate remains for 12 hours, (+++) Gelation immediate remains for more than 12 hours
Table 5.6: Content Uniformity of In-Situ Gel formulation of etodolac S.NO Formulation code Content …show more content…
All the formulations were off white to pale yellow colored solution. They have pH in the range of 7.02 – 7.30 (Table 5.2). Viscosity of the formulation was determined using Brookfeild viscometer and the viscosity of the formulation increased with an increase in sodium alginate and pectin concentration (Table 5.3). This phenomenon is a consequence of increasing chain interaction with an increase in polymer concentration. The change in viscosity is proportional to the change in concentration and polymer ratio.
The buoyancy lag time in simulated gastric fluid (0.1 mol L-1HCL, pH 1.2) varied with the formulation variables. Formulation P1 exhibited the least buoyancy lag time (26 s) while formulation P6 exhibited the highest lag time (219 s) (Table 5.4) (Figure 5.1 and 5.2). The decrease in the buoyancy lag time of a formulation P1 can be attributed to the availability of an increase amount of carbon dioxide with concentration of calcium carbonate which was entrapped in the formed gel to give rapid buoyancy. Irrespective of formulation variables, buoyancy duration was >12