Antipsychotic Synthesis Lab Report
Photolytic Degradation of Flupentixol-Melitracen
Chapter One
Introduction
1
Photolytic Degradation of Flupentixol-Melitracen
2
1. ANTIPSYCHOTIC
1.1 Antipsychotic
An antipsychotic also known as neuroleptic is a tranquilizing psychiatric medication which is used to treat psychosis, schizophrenia and bipolar disorder. Now it is increasingly being used to treat the non-psychotic disorders. Psychosis disorder included delusions or hallucinations.
Delusion is the pathological condition that is the result of an illness or progressing of illness. A first generation of antipsychotics was discovered in the 1950s which is known as typical antipsychotics. Atypical antipsychotics have been developed as a second generation drug
recently. …show more content…
1
2
3
4
5
Concentration (mg/ml)
0.2
0.04
0.008
0.0016
0.00032
Using UV-Spectrophotometer absorbance was taken above all the solution for flupentixol dihydrochloride (at 229 nm wavelength) and for melitracen hydrochloride (at 258 nm wavelength). The observed value was plotted against concentration and a linear regression equation was obtained.
3.2.2 Sample collection
To determine the photo stability of the drug the tablets were subjected to various types of photo exposure, which are:
Electric Bulb exposure (25 watt, 40 watt)
Sunlight exposure(summer)
Exposure to normal room temperature (14 days, 28 days, 42 days)
3.2.2.1 Electric Bulb exposure (25 watt, 40 watt)
Two power ranges of bulb, 25 watt and 40 watt were used as the artificial light source.
Thirty tablets were kept on a solid surface and were placed under 25 watt containing lamp. A thermometer was kept behind the tablets submerge in a glass of water to measure the temperature. We kept the tablets for nine hour and after each three hour 10 tablet were collected.
In three hour 10 tablets where collected as 3 hour exposed sample and with more 3 hour the
Chapter One
Introduction
1
Photolytic Degradation of Flupentixol-Melitracen
2
1. ANTIPSYCHOTIC
1.1 Antipsychotic
An antipsychotic also known as neuroleptic is a tranquilizing psychiatric medication which is used to treat psychosis, schizophrenia and bipolar disorder. Now it is increasingly being used to treat the non-psychotic disorders. Psychosis disorder included delusions or hallucinations.
Delusion is the pathological condition that is the result of an illness or progressing of illness. A first generation of antipsychotics was discovered in the 1950s which is known as typical antipsychotics. Atypical antipsychotics have been developed as a second generation drug
recently. …show more content…
1
2
3
4
5
Concentration (mg/ml)
0.2
0.04
0.008
0.0016
0.00032
Using UV-Spectrophotometer absorbance was taken above all the solution for flupentixol dihydrochloride (at 229 nm wavelength) and for melitracen hydrochloride (at 258 nm wavelength). The observed value was plotted against concentration and a linear regression equation was obtained.
3.2.2 Sample collection
To determine the photo stability of the drug the tablets were subjected to various types of photo exposure, which are:
Electric Bulb exposure (25 watt, 40 watt)
Sunlight exposure(summer)
Exposure to normal room temperature (14 days, 28 days, 42 days)
3.2.2.1 Electric Bulb exposure (25 watt, 40 watt)
Two power ranges of bulb, 25 watt and 40 watt were used as the artificial light source.
Thirty tablets were kept on a solid surface and were placed under 25 watt containing lamp. A thermometer was kept behind the tablets submerge in a glass of water to measure the temperature. We kept the tablets for nine hour and after each three hour 10 tablet were collected.
In three hour 10 tablets where collected as 3 hour exposed sample and with more 3 hour the