Analyzing the genetic characteristics of both retinoblastoma’s types, mainly the mutations on a tumor suppressor gene named Rb, Kudson theorized the “two-hit hypothesis”. He stated that sporadic retinoblastoma arises through the gaining of two new random somatic mutations. In contrast, the familial form demands only one somatic mutation to develop,
Analyzing the genetic characteristics of both retinoblastoma’s types, mainly the mutations on a tumor suppressor gene named Rb, Kudson theorized the “two-hit hypothesis”. He stated that sporadic retinoblastoma arises through the gaining of two new random somatic mutations. In contrast, the familial form demands only one somatic mutation to develop,