CDKN2A: this gene is the most commonly mutated in genetically-inherited melanoma but still presents in those with those diagnosed with non-genetic melanoma. This mutation causes misshapen and dark moles and is often diagnosed early in life.
MC1R: this gene is the one responsible for determining a person’s sensitivity to light. It also plays a key role in determining red hair color, fair skin and ability to tan. Those with darker skin have more than one of these genes and tend to develop skin cancer more frequently.
MDM2: more prevalent mutations in women diagnosed with cancer, this gene determines how many copies are made within a cell and is exaggerated by a predisposition to UV sensitivity.
BRF, P16, EGF and Fas are genes that are mutated by environmental factors and are predominately forced into mutation by exposure to UV light.
In addition to genes, we also have melanin that is present in our bodies that is a determining factor in the color of our hair, skin and eyes. While everyone has melanin in their cells, the amount from person to person is not equal. The more melanin present in your skin, the darker your complexion will be. The different types of melanin present in the iris produce pigmentation there, and these factors are largely dependent