Current Medicinal Chemistry‚ 2011‚ 18‚ 733-766 733 New Lead Structures in Antifungal Drug Discovery Chunquan Sheng and Wannian Zhang* Department of Medicinal Chemistry‚ School of Pharmacy‚ Second Military Medical University‚ 325 Guohe Road‚ Shanghai 200433‚ People’s Republic of China Abstract: During the past two decades‚ the incidence of invasive fungal infections has been increasing dramatically. Clinical available antifungal agents have several drawbacks such as limited potency and
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Candidate name…………………………………………………………………….. MINISTRY OF EDUCATION MASALA SECONDARY SCHOOL BOARD MOCK EXAMINATION 2014 SCIENCE 5124/3 PAPER 3 (CHEMISTRY) 1hour 15minutes Additional materials: Monday 30th July 2014. Answer paper INSTRUCTIONS TO CANDIDATES Write your name‚ centre number and candidate number at the top of this page all separate Attempt all questions in SECTION A and only TWO questions in SECTION B SECTION A (45 marks)
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Chemistry Review (mid-term) 1. Use the equation for atomic mass to answer the following questions. (http://johnheilchem10.escuelacampoalegre.wikispaces.net/file/view/average+atomic+mass+calculations+-+3.pdf) 1. Argon has three naturally occurring isotopes: argon-36‚ argon-38‚ and argon-40. Based on argon’sreported atomic mass‚ which isotope do you think is the most abundant in nature? Explain. 2. Copper is made of two isotopes. Copper-63 is 69.17% abundant and it has a mass of 62.9296 amu.
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What is Chemistry? Chemistry is the study of matter and energy and the interactions between them. This is also the definition for physics‚ by the way. Chemistry and physics are specializations of physical science. Chemistry tends to focus on the properties of substances and the interactions between different types of matter‚ particularly reactions that involve electrons. Physics tends to focus more on the nuclear part of the atom‚ as well as the subatomic realm. Really‚ they are two sides of the
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Separation of a Mixture of Solids PURPOSE: The purpose of this lab is to familiarize ourselves with the techniques associated with separating a mixture of different solids. We will learn how the unique properties of substances can aid in this process and help us distinguish each pure substance from one another. DATA OBSERVATIONS CALCULATIONS CONCLUSION/DISCUSSION QUESTIONS A. How did your proposed Procedures or flow charts at the beginning of this experiment compare to the actual Procedures
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Baking Project There are several chemical reactions taking place in the general baking of cakes. Every ingredient has its own function and causes a different reaction Synthesis: * Egg yolks (modify molecule’s structure) helps the oil-based and water-based components of the cake mix together. When eggs are cooked‚ the protein molecules become uncurled when exposed to heat and create new molecular bonds with other nearby protein molecules. When the egg is completely cooked‚ it helps form a
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Isotopes and average atomic mass Isotope: element variations with different atomic mass but same atomic number Isotopic Abundance: the relative amount in which each isotope of an element Calculating: given 2 isotopes of an element [B: 10.01u] [B: 11.01u] 1) Given average atomic mass: 10.81u If given percentages‚ you can find average atomic mass by adding each portion 2) Set variables for unknown values Let x represent % abundance for 10/5 B Let 1-x represent % abundance for 11/5 B Calculate:
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Abstract By adding HCl to 2-methyl-2-butanol‚ through the Sn1 mechanism‚ 2-chloro-2-methylbutane is formed. Water‚ sodium bicarbonate and NaCl(aq) were then added to the 2-chloro-2-methylbutane to remove any of the excess water from the reaction. To confirm‚ a successful reaction‚ AgNO3 was added to the 2-chloro-2-methylbutane. A white precipitate formation confirmed a successful Sn1 reaction. Introduction Nucleophilic substitution reactions such as Sn1 and Sn2 allow us to convert one functional
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Absorbance of Light vs. Concentration of Colored Solution Introduction: Performing this lab showed the importance of light in virtual drug screening because light can be used in a variety of ways to obtain different kinds of information in research. Light can be used to determine the concentration of DNA or protein in solution‚ tag different objects such as cells‚ protein structures‚ or bacteria in order to determine whether there is a large amount of a certain substance‚ and to determine the size
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Module 4: 10. Strong Bases: NaOH‚ KOH‚ Na2CO3‚ NaHCO3‚ Na3PO4‚ NaHPO4‚ Strong Acids: Fe(NO3)3‚ HCL‚ HNO3‚ Al(NO3)3‚ NiCl2‚ H2SO4 11. Acidic Neutral Basic NaCl KNO3 NaOH HC2H3O2 Na2CO3 NaC2H3O2 NaHCO3 Fe(NO3)3 NaNO3 Na3PO4 HCl MgSO4 KOH HNO3 Na2SO4 NaHPO4 CuSO4 NaNO2 CoCl2 Al(NO3)3 NiCl2 H2SO4 KCl NH4Cl 12. CuSO4 CuCO3.Cu(OH)2(s) + 2 H2SO4(aq) ----> 2 CuSO4(aq) + CO2(g) + 3 H2O(l) Na3PO4 Na3PO4 (aq) + 3H2O (l) --> H3PO4 (aq) + 3NaOH
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