ACUTE-ON-CHRONIC LIVER FAILURE: APPLYING THE PIRO CONCEPT Danielle Adebayo‚ Vincenzo Morabito‚ Rajiv Jalan Liver Failure Group‚ UCL Institute for Liver and Digestive Health‚ UCL Medical School‚ Royal Free Hospital‚ London‚ UK Disclosure: No potential conflict of interest Citation: EMJ Hepatol. 2013;1:38-43. ABSTRACT Acute-on-chronic liver failure (ACLF)‚ a clinical syndrome associated with a dismal prognosis‚ occurs acutely in previously stable cirrhotic patients. An important feature
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2LIVER Anatomical overview What is liver? The whole liver together weighs 3-4 pounds. It is from a light pink to a dark red color. The liver is located right below the heart. The liver is a very big organ. The liver and gallbladder are responsible for a number of functions. One of the main functions is to help in digestion. The largest solid organ in the body‚ situated in the upper part of the abdomen on the right side. The liver has a multitude of important and complex functions
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Is an Enlarged Liver a Serious Condition? Enlarged liver is a term some individuals use to describe what doctors call Hepatomegaly. It is also called swollen liver. The phrases swollen liver or enlarged liver are self-explanatory. So the question becomes‚ what is the cause of enlarged liver‚ and how serious a health threat can it be? It should be stated at the start that swollen liver is not a disease itself. It is a sign of some specific liver infection‚ damage or a part of an abnormal
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Pathophysiology of Metastatic Liver Cancer Liver metastases are cancerous tumors that have spread to the liver from somewhere else in the body. Cancers that may spread to the liver include: • Breast cancer • Colorectal cancer • Esophageal cancer • Lung cancer • Melanoma • Pancreatic cancer • Stomach cancer The risk of cancer spreading to the liver depends on the site of the original cancer. A liver metastasis may be present when the original (primary) cancer is diagnosed‚ or it may
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chronic liver disease. Liver disease is any condition that causes liver inflammation or tissue damage and affects liver function. Some important function of liver are to convert the food we eat into stored energy and chemicals necessary for life and growth‚ to act as a filter to remove alcohol and toxic substances from the blood‚ and to manufacture and export important body chemicals used by the body. Liver disease is dangerous and it can effect the body. The liver has many functions‚ so liver disease
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Critical Summary 3 ("Alcoholics and Liver Transplantation") Many moral‚ ethical‚ and medical issues are raised in “Alcoholics and Liver Transplants” (JAMA‚ March 13‚ 1991‚ Vol. 265‚ pp. 1299-1301). The authors‚ Carl Cohen and Martin Benjamin dissect the many arguments against giving liver transplants to those who abuse alcohol. Alcoholic cirrhosis of the liver‚ severe scarring due to the heavy use of alcohol is by far the major cause of end-stage liver disease. Cohen and Martin do not believe
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describe the structure and function of the heart‚ it will also explain the meaning of Atherosclerosis and how it can lead to myocardial infarctions and angina. It will also discuss and identify the factors that can increase the risk of Coronary Heart Disease and how lifestyle changes can prevent it. The main function of the human heart is to pump blood around the body. It is a muscular cone shaped organ‚ the average size of the human heart is the size of a clenched fist and weights on average eleven
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The kidney and the liver are two of the four major routes a drug takes when trying to leave the body. If someone has kidney or liver disease‚ how a person’s body handles that drug is greatly affected. Drinks‚ food and or lifestyle habits that put added stress and cause damage to your kidneys or liver‚ foe example alcohol abuse or chronic exposure to toxins such as paint fumes‚ can affect how well you process drugs. Kidney and or liver stress/damage usually raises drug levels a lot higher than normal
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as yellow skin or eyes disease. It turns your skin‚ mucous membranes‚ sclera (the white of your eyes) into a single yellow color. This yellow pigment which is seen on your skin is due to bilirubin which is a byproduct of old red blood cells. If you are affected by jaundice consider it to be a serious problem which cannot to be taken lightly. Nearly 1% red blood cells retire everyday and those are replaced by fresh blood cells. These old blood cells are processed in the liver and later disposed. If
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Gaucher ’s Disease is an autosomal metabolic disorder. This means that it is inherited from both parents. For a child to develop the disease both the mother and the father must to carry the necessary gene. If in fact the child inherits the disease he or she will experience problems with the liver‚ spleen‚ lungs‚ bone marrow‚ and in some cases the brain. The disease is caused by excessive amounts of a fatty substance called glucocerebroside. Glucocerebroside accumulates in the organs when there is
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