Tay-Sachs Disease History: The disease is named for Warren Tay (1843-1927)‚ a British ophthalmologist who in 1881 described a patient with a cherry-red spot on the retina of the eye. It is also named for Bernard Sachs (1858-1944)‚ a New York neurologist whose work several years later provided the first description of the cellular changes in Tay-Sachs disease. Sachs also recognized the familial nature of the disorder‚ and‚ by observing numerous cases‚ he noted that most babies with Tay-Sachs
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Emma Goldman perseverance towards equal rights‚ views on women‚ and reorganizing politics especially for women earned her‚ her place in history. Emma was born in Lithuania‚ but she moved to a czarist Russian ghetto called Kovno until 1886.(“Was My Life Worth Living?”‚ 2000) Her father discouraged her from having an education‚ and he told her that her only meaning in life was marrying and having a family.(“Emma Goldman: Overview‚ 2003) She moved to New York to live with her sister Lena at the age
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Tay-Sachs is a devastating disease affecting lysosomal storage. According to McCance & Huether (2014)‚ it is due to a deficiency in the lysosomal enzyme hexosaminidates A (HexA) that’s function is to degrade GM2 gangliosides (fatty acids) in nerve cells. Those diagnosed with Tay-Sachs do not have the ability to degrade this fatty acid and as a result‚ it builds up in the body causing nerve cell toxicity. It is genetically inherited through an autosomal recessive pattern meaning that both parents
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Many people in society today are having casual sex outside of the marriage more and more. Has sex lost its true purpose and morality? If so‚ is this correct and morally acceptable? Alan Goldman and Roger Scruton see sex and the morality of sex very different. Goldman believes sex is just that‚ sex between two people for pleasure while Scruton believe sex should always have love and emotion with a spouse or long term relationship. What is the true morality of sex and who is correct? Sex should
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Centre for Management Technology Knowledge Park I Gr. Noida Acknowledgements If words are considered to be signs of gratitude then let these words Convey the very same My sincere gratitude to ICICI BANK for providing me with an opportunity to work with BANK and giving necessary directions on doing this project to the best of my abilities. I am highly indebted to Mr.Remay Verma‚ Branch Manager and Mr. Ravi Parmar (RM) company project guide‚ who has provided me with
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No. 3. May 2013 Issue. Pp. 71 – 88 Performance Appraisal of Indian Public Sector Banks Parvesh Kumar Aspal * and Naresh Malhotra** The strength of economy of any country basically hinges on the strength and efficiency of financial system‚ which‚ in turn‚ depends upon a sound banking system. The regulators have recommended bank’s supervision through CAMEL rating model to assess the performance of banks‚ which is better than the earlier systems. The prime objective of CAMEL model of rating
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Tay-Sachs is a rare genetic disorder that slowly destroys nerve cells in the brain and spinal cord and this disease effects millions of people (Tay-Sachs GHR). Tay-Sachs can’t be spread as it’s a genetic disorder. It is caused by a genetic mutation in the HEXA genes (Tay-Sachs GHR). People who have Tay-Sachs have problems with the enzyme called beta hexosamidase A and this enzyme is supposed to clean up the buildup of the molecule called GM2 ganglioside within cells but if it doesn’t it leads to
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alludes to bank secrecy and minimizing taxes through careful allocation of assets‚ or by hiding assets from the taxing authorities. Swiss and certain offshore bankshave been criticized for such cooperation with individuals practicing tax evasion. Although tax fraud is a criminal offense in Switzerland‚ tax evasion is only a civil offence‚ not requiring banks to notify taxing authorities.[3] Historically‚ private banking has developed in Europe (see the List of private banks). Some banks in Europe
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What is Tay-Sachs Disease? Tay-Sachs disease is a fatal genetic lipid storage disorder in which harmful quantities of a fatty substance called ganglioside GM2 build up in tissues and nerve cells in the brain. The condition is caused by insufficient activity of an enzyme called beta-hexosaminidase A that catalyzes the biodegradation of acidic fatty materials known as gangliosides. Gangliosides are made and biodegraded rapidly in early life as the brain develops. Infants with Tay-Sachs disease appear
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INVESTMENT BANKS As with commercial banks‚ investment banks are highly leveraged entities that play important roles in both the primary and secondary markets. Investment banking activities include: • Raising funds through public offerings and private placement of securities. • Trading of securities. • Mergers‚ acquisitions‚ and financial restructuring advising. • Merchant banking. • Securities finance and prime brokerage services. The first role is assisting in the raising of funds by
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