CCK-8 assay and FITC apoptosis detection kit will detect a low to no cellular proliferation and apoptosis. This is due to AFB1 not being present and therefore not contributing to the upregulation of miR-155. In the case of the experimental rats‚ RT-qPCR will present a large amount of miR-155 expression levels. Moreover‚ CCK-8 assay and FITC will show an increased rate of cellular proliferation and a decrease in cellular apoptosis respectively. An indication that AFB1 toxin
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cell to divide (Weinberg 2014). P53 is considered the “guardian of the genome” due to its variety of functions that are crucial for regular cell life cycles‚ and can prevent cancer (Weinberg 2014). Some of the functions of p53 include regulation of apoptosis‚ inducing cell-growth arrest‚ and activation of DNA repair proteins when the cellular DNA is damaged (Weinberg). Due to the majority of these functions preventing cancer and protecting the genome‚ one can see where the title “guardian of the genome”
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University‚ 3Cardiovascular & Metabolic Disease Center‚ Inje University‚ Gimhae‚ Gyeongnam 621-749‚ Korea Abstract Doxorubicin (DOX) has been known as strong therapeutic effective in cancers. DOX induced oxidative stress may cause necrosis apoptosis and left ventricular dysfunction and cardiac toxicity. We have known that melatonin protects against DOX induced cardiac damage. Also therapeutic exercise potential improve the ejection‚ left ventricle filling‚ due to reduction of myocardial oxidative
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the growth in inhibition induced by kola nut extract fellow a dose- and time- dependent response? 3- Does kola nut extract induce apoptosis or necrosis? 4- Which cell line‚ a K562 or Jurkat cell line is more sensitive to this targeted extract? 4-METHODOLOGY 4-1 Study design The design of our study is a type of case-control design‚ where the induction of apoptosis on both the myeloid (K562) and lymphoid (Jurkat) human cell lines by kola nut extract will be investigated. The design of the experiment
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the 19th century that chickenpox was reliably distinguished from small pox. H. herpesvirus-3 can code for anti-apoptotic proteins that interferes with the apoptosis pathway. Apoptosis is the programed death of a cell once it knows that it has been infected‚ because H. herpesvirus-3 encodes for anti-apoptotic proteins‚ it is able to evade apoptosis and keep the infected cell alive therefore ensuring that its DNA can replicate within that cell without the infected cell dying.
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with repaired DNA to divide. When DNA can’t be repaired‚ then the cell goes under apoptosis (death of the cell). However when this gene is turned off or it isn’t able to destruct damaged DNA‚ then the cell with the damaged DNA is able to divide continuously which may cause cancer. This means that for cancer to occur all p53 genes have to be non-active or stopped. Since p53‚ signals for the repair or apoptosis of the cell‚ when this gene is mutated cells containing dangerous DNA is able to divide
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Contents Oncogene An oncogene is a kind of abnormal gene that predisposes cells to develop into cancers. Unlike normal genes‚ which can be turned off after being turned on‚ oncogenes are altered in a way that keeps them stuck in a state of constant activity. That uninterrupted action helps drive the uncontrolled growth that underlies tumors. Oncogenes can be turned on by inherited changes - ones that are passed down from parent to child - or by cancer-promoting agents that
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Chapter 11: Cell Communication Concept 11.1 External signals are converted to responses within the cell. I. Evolution of Cell Signaling 1. signal transduction pathway. a specific cellular response in a series of steps 2. signaling mechanisms first evolved in ancient prokaryotes and unicellular eukaryotes‚ then adopted for new uses 3. quorum sensing. allows bacterial populations to coordinate behaviors to carry out activities only productive when performed by a given number of cells
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different types of transporters in cell membrane……………....07 Task 02 2.1 Explain how in each stage of Interphase‚ mitosis and controlling agents involved to contribute to the formation of identical cells………………….12 2.2 The importance of apoptosis pathway in liver cells………………………………..15 Reference………………………………………………………………………………...17 Task 01 1.1 How Archaea is similar to Eukaryotes and how they differ from Bacteria. Once classified as bacteria in the domain prokaryotes
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members‚ including growth differentiation factors (GDFs) and TGFβ. They are involved in the regulation of various biological functions such as proliferation‚ differentiation‚ migration‚ and apoptosis in many different cell types (-).
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