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The Relationship Between Dysfunction of the Prefrontal Cortex and Antisocial Behaviour

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The Relationship Between Dysfunction of the Prefrontal Cortex and Antisocial Behaviour
Review the relationship between dysfunction of the prefrontal cortex and antisocial behaviour
There is evidence for a relationship between dysfunction of the prefrontal cortex and antisocial behaviour, but as to whether this evidence is strong enough to have a definitive answer is yet to be discovered. The prefrontal cortex is a complex and highly developed part of the brain making up the majority of the frontal lobe (Bear, Connors & Paradiso, 2001). It is believed that the prefrontal cortex is involved in the regulation of cognition and behaviour therefore playing a key role in our emotions and social interactions. Antisocial behaviour is a broad term covering any behaviour that causes damage and conflicts with the interests of society. This therefore includes violence, inappropriate behaviour, lack of empathy and verbal abuse which has all be associated to dysfunction of the prefrontal cortex. The prefrontal cortex plays a major role in social cognition. This is an umbrella term used for the cognitive processes for social interaction, such as inhibitory control, correct behavioural responses, and theory of mind. When damage is caused to inhibitory control it leads to emotional instability. Behaviour becomes childish, argumentative, becoming irritable quickly and finding difficulty to control mood changes (Hawkins & Trobst, 2000). Many studies have supported this idea, one in a particular, the case of Phineas Gage, foreman of a railway construction crew. An accident involving explosives sent the rod into his head and through his left frontal lobe. He survived, however his personality completely changed. From an efficient, lively character he turned into someone who was childish, impatient and irresponsible. Damasio et al (1994, as described by Carlson (2010)) believed the reason for this was due to the rod destroying the ventromedial prefrontal cortex which when functioning normally, suppresses emotional responses to suit the situation. This



References: Bear, M.F., Connors, B.W. & Paradiso, M.A. (2001). Neuroscience: Exploring The Brain (2nd Edition). Pennsylvania: Lippincott Williams & Wilkins Best, M., Williams, J.M. & Coccaro, E.F. (2002) Evidence for a dysfunctional prefrontal circuit in patients with an impulsive aggressive disorder. Proceedings of the National Academy of Sciences of the United States of America, 99, 8448–8453 Carlson, N.R. (2010). Physiology of Behaviour (10th Edition). Boston: Allyn & Bacon Damasio, H., Grabowski, T., Frank, R., Galaburda, A.M. & Damasio, A.R. (1994). The Return of Phineas Gage: Clues about the brain from the skull of a famous patient. Science, 264, 1102-1105 Eslinger, P.J., Flaherty-Craig, C.V. & Benton, A.L. (2004). Developmental outcomes after prefrontal cortex damage. Brain and Cognition, 55, 84-103 Grafman, J., Schwab, K., Warden, D., Pridgen, A., Brown, H. R. & Salazar, A. M. (1996). Frontal lobe injuries, violence, and aggression: A report of the Vietnam Head Injury Study. Neurology, 46, 1231–1238. Hawkins, K.A. & Trobst, K.K. (2000). Frontal Lobe Dysfunction and Aggression: Conceptual Issues and Research Findings. Aggression and Violent Behaviour, 5, 147-157 Karim, A.A., Schneider, M., Lotze, M., Veit, R., Sauseng,P., Braun, C. & Birbaumer, N. (2010). The Truth about Lying: Inhibition of the Anterior Prefrontal Cortex Improves Deceptive Behavior. Cerebral Cortex, 20, 205-213 Moll, J., Zhan, R., Oliveira-Souza, R., Krueger, F. and Grafman, J. (2005). The neural basis of human moral cognition. Neuroscience, 6, 799-809 Uekermann, J. & Daum, I. (2008) Social cognition in alcoholism: a link to prefrontal cortex dysfunction. Addiction, 103, 725-735

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