Simvastatin Solubility
Solubility is a rate limiting dissolution process for a drug included in a BCS class II system to increase the bioavailability [1]. Drug which has a low solubility but high permeability needs to be improved and modified so it would have a better therapeutically impact. Simvastatin is member of statin group used to decrease the hypercholesterolemia by inhibits the HMG-CoA reductase enzyme which has a role in forming a cholesterol [2]. Simvastatin is a white powder crystalline, non-hygroscopic, 418.56 molecular weight. Practically insoluble in water (30 µg/mL) easily dissolved in methanol, ethanol and chloroform. It has a bioavailability in 3 hours and 5% [3, 4]. Simvastatin included in class II based on Biopharmaceutical Classification System