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Orodispersible Tablets

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Orodispersible Tablets
Deepak et al

Journal of Drug Delivery & Therapeutics; 2012, 2(3): 74-86
Available online at http://jddtonline.info

74

REVIEW ARTICLE FAST DISINTEGRATING TABLETS: A NEW ERA IN NOVEL DRUG DELIVERY SYSTEM AND NEW MARKET OPPORTUNITIES
*Sharma Deepak, Kumar Dinesh, Singh Mankaran, Singh Gurmeet, Rathore M.S
CT Institute of Pharmaceutical Sciences, Shahpur, P.O- Udopur, Near Lambra, Jalandhar -144020, Punjab, INDIA *Corresponding Author’s Email: deepakpharmacist89@yahoo.com, M obile: 09988907446 Received 15 M arch 2012; Revised 13 April 2012; Accepted 21 April 2012, Available online 15 M ay 2012 ABS TRACT Fast disintegrating tablets (FDTs) have received ever-increasing demand during the last decade and the field has become a rapidly growing area in the pharmaceutical industry. Fast disintegrating tablets (FDTs) are those solid dosage forms when put on tongue, disintegrate or dissolve instantaneously, releasing the drug, within a few seconds without the need of water. Fast disintegrating tablets (FDTs) aim for designing dosage forms, convenient to be manufactured and administered, free of side effects, offering immediate release and enhanced bioavailability, to achieve better patient compliance. Fast disintegrating tablets have been formulated for p ediatric, geriatric, and bedridden patients and for active patients who are busy and traveling and may not have access to water. Such formulations provide an opportunity for product life extension in the many elderly persons which have difficulty in taking conventional oral dosage form (viz., solutions, suspensions, tablets, and capsules) because of hand tremors and dysphagia. The current article is focused on ideal requirements, need for development of FDTs, challenges in formulation, suitability of drug candidates, superdisintegrants employed, various technologies developed for FDTs, patented technologies like Wowtab, Durasolv, Orasolv, Flashtab, Zydis, Frosta technology, Sheaform, Ceaform technology, Nanocrystal
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