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Modulation of gene
Journal of Biomaterials
Applications
http://jba.sagepub.com/

Modulation of Gene Expression of Rabbit Chondrocytes by Dynamic
Compression in Polyurethane Scaffolds with Collagen Gel Encapsulation
Peng-Yuan Wang, Hsiang-Hong Chow, Wei-Bor Tsai and Hsu-Wei Fang
J Biomater Appl 2009 23: 347 originally published online 12 August 2008
DOI: 10.1177/0885328208093684
The online version of this article can be found at: http://jba.sagepub.com/content/23/4/347 Published by: http://www.sagepublications.com Additional services and information for Journal of Biomaterials Applications can be found at:
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Modulation of Gene Expression of
Rabbit Chondrocytes by Dynamic
Compression in Polyurethane
Scaffolds with Collagen Gel
Encapsulation
PENG-YUAN WANG, HSIANG-HONG CHOW AND WEI-BOR TSAI*
Department of Chemical Engineering, National Taiwan University
Taipei, Taiwan

HSU-WEI FANG
Department of Chemical Engineering and Biotechnology
National Taipei University of Technology, Taipei, Taiwan

ABSTRACT: Chondrocytes have been demonstrated to be sensitive to mechanical stimuli, such as compression, tension, shear force, and hydrostatic pressure.
The responses of chondrocytes to mechanical compression have been often studied in vitro with cartilage and chondrocyte/hydrogel systems. The aim of this study was to investigate the effects of dynamic compression on gene expression of rabbit chondrocytes which were seeded in elastic polyurethane scaffolds with or without collagen gel encapsulation. Dynamic compression of 20% or 30%


Citations: http://jba.sagepub.com/content/23/4/347.refs.html >> Version of Record - Jan 6, 2009 OnlineFirst Version of Record - Aug 12, 2008 What is This? Downloaded from jba.sagepub.com by guest on July 3, 2013 Modulation of Gene Expression of Los Angeles, London, New Delhi and Singapore Downloaded from jba.sagepub.com by guest on July 3, 2013 Downloaded from jba.sagepub.com by guest on July 3, 2013 Modulation of Gene Expression of Chondrocytes by Dynamic Compression 349
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