MRI In Alzheimer's Disease
ROLE OF MRI IN ALZHEIMER’S DISEASE
INTRODUCTION
Alzheimer’s disease is the most common causes of dementia, responsible for 60-80% of all dementias 2, 7. The prevalence is strongly linked to age, with >1% of 60-64-year-old patients being diagnosed with the condition, compared to 20-40% of those over 85-90 years of age 2. It is multifaceted disease which results in progressive cognitive decline that ultimately leads to dementia. Amyloid plaques and neurofibrillary tangles are considered as diagnostic tools for this disease. AD is characterized by an insidious onset and inexorable progression of atrophy that is the first manifestation in the medial temporal lobe (Scahill et al 2002).
Nowadays role of imaging is being increased to probe the …show more content…
Kawachi T, Ishii K, Sakamoto S, Sasaki M, Mori T, Yamashita F, Matsuda H, Mori E: Comparison of the diagnostic performance of FDG-PET and VBM-MRI in very mild Alzheimer's disease. Eur J Nucl Med Mol Imaging. 2006, 33: 801-809. 10.1007/s00259-005-0050-
5. Matsunari I, Samuraki M, Chen WP, Yanase D, Takeda N, Ono K, Yoshita M, Matsuda H, Yamada M, Kinuya S: Comparison of 18F-FDG PET and optimized voxel-based morphometry for detection of Alzheimer's disease: aging effect on diagnostic performance. J Nucl Med. 2007, 48: 1961-1970. 10.2967/jnumed.107.042820.
6. Walhovd KB, Fjell AM, Amlien I, Grambaite R, Stenset V, Bjørnerud A, Reinvang I, Gjerstad L, Cappelen T, Due-Tønnessen P, Fladby T: Multimodal imaging in mild cognitive impairment: metabolism, morphometry and diffusion of the temporal-parietal memory network. Neuroimage. 2009, 45: 215-223. 10.1016/j.neuroimage.2008.10.053
7. Walhovd KB, Fjell AM, Brewer J, McEvoy LK, Fennema-Notestine C, Hagler DJ, Jennings RG, Karow D, Dale AM, Alzheimer's Disease Neuroimaging Initiative: Combining MR imaging, positron-emission tomography, and CSF biomarkers in the diagnosis and prognosis of Alzheimer disease. AJNR Am J Neuroradiol. 2010, 31: 347-354.
INTRODUCTION
Alzheimer’s disease is the most common causes of dementia, responsible for 60-80% of all dementias 2, 7. The prevalence is strongly linked to age, with >1% of 60-64-year-old patients being diagnosed with the condition, compared to 20-40% of those over 85-90 years of age 2. It is multifaceted disease which results in progressive cognitive decline that ultimately leads to dementia. Amyloid plaques and neurofibrillary tangles are considered as diagnostic tools for this disease. AD is characterized by an insidious onset and inexorable progression of atrophy that is the first manifestation in the medial temporal lobe (Scahill et al 2002).
Nowadays role of imaging is being increased to probe the …show more content…
Kawachi T, Ishii K, Sakamoto S, Sasaki M, Mori T, Yamashita F, Matsuda H, Mori E: Comparison of the diagnostic performance of FDG-PET and VBM-MRI in very mild Alzheimer's disease. Eur J Nucl Med Mol Imaging. 2006, 33: 801-809. 10.1007/s00259-005-0050-
5. Matsunari I, Samuraki M, Chen WP, Yanase D, Takeda N, Ono K, Yoshita M, Matsuda H, Yamada M, Kinuya S: Comparison of 18F-FDG PET and optimized voxel-based morphometry for detection of Alzheimer's disease: aging effect on diagnostic performance. J Nucl Med. 2007, 48: 1961-1970. 10.2967/jnumed.107.042820.
6. Walhovd KB, Fjell AM, Amlien I, Grambaite R, Stenset V, Bjørnerud A, Reinvang I, Gjerstad L, Cappelen T, Due-Tønnessen P, Fladby T: Multimodal imaging in mild cognitive impairment: metabolism, morphometry and diffusion of the temporal-parietal memory network. Neuroimage. 2009, 45: 215-223. 10.1016/j.neuroimage.2008.10.053
7. Walhovd KB, Fjell AM, Brewer J, McEvoy LK, Fennema-Notestine C, Hagler DJ, Jennings RG, Karow D, Dale AM, Alzheimer's Disease Neuroimaging Initiative: Combining MR imaging, positron-emission tomography, and CSF biomarkers in the diagnosis and prognosis of Alzheimer disease. AJNR Am J Neuroradiol. 2010, 31: 347-354.