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How the sense of Smell works

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How the sense of Smell works
Olfaction or olfactory perception[1] is the sense of smell. This sense is mediated by specialized sensory cells of the nasal cavity of vertebrates, which can be considered analogous to sensory cells of the antennae of invertebrates. In humans, olfaction occurs when odorant molecules bind to specific sites on the olfactory receptors. These receptors are used to detect the presence of smell. They come together at the glomerulus, a structure which transmits signals to the olfactory bulb (a brain structure directly above the nasal cavity and below the frontal lobe).[2] Many vertebrates, including most mammals and reptiles, have two distinct olfactory systems—the main olfactory system, and the accessory olfactory system (used mainly to detect pheromones). For air-breathing animals, the main olfactory system detects volatile chemicals, and the accessory olfactory system detects fluid-phase chemicals.[3] Olfaction, along with taste, is a form of chemoreception. The chemicals themselves that activate the olfactory system, in general at very low concentrations, are called odorants. Although taste and smell are separate sensory systems in land animals, water-dwelling organisms often have one chemical sense.[4]

Volatile small molecule odorants, non-volatile proteins, and non-volatile hydrocarbons may all produce olfactory sensations. Some animal species are able to smell carbon dioxide in minute concentrations. Taste sensations are caused by small organic molecules and proteins.[5]

Contents

1 Study of olfaction 2 Main olfactory system 2.1 Receptor neuron 2.2 Olfactory bulb projections 3 Accessory olfactory system 4 Human olfactory system 5 Olfactory coding and perception 6 Genetics of olfaction 7 Interactions of olfaction with other senses 7.1 Olfaction and taste 7.2 Olfaction and audition 8 Disorders of olfaction 9 Quantifying olfaction in industry 10 Olfaction in plants and animals



References: Jump up ^ Daniel Schacter, Daniel Gilbert, Daniel Wegner (2011). "Sensation and Perception". Psychology. Worth Publishers. p. 166-171. ISBN 978-1-4292-3719-2. Jump up ^ USA (2012-10-19). "Better Smelling Through Genetics: Mammalian Odor Perception". Ncbi.nlm.nih.gov. Retrieved 2012-12-30. Jump up ^ Buck L, Axel R (April 1991). "A novel multigene family may encode odorant receptors: a molecular basis for odor recognition". Cell 65 (1): 175–87. doi:10.1016/0092-8674(91)90418-X. PMID 1840504. Jump up ^ Gilad Y, Man O, Pääbo S, Lancet D (March 2003). "Human specific loss of olfactory receptor genes". PNAS 100 (6): 3324–7. doi:10.1073/pnas.0535697100. PMC 152291. PMID 12612342. Jump up ^ Pinel, John P.J. (2006) Biopsychology. Pearson Education Inc. ISBN 0-205-42651-4 (page 178) Jump up ^ Turin L (December 1996) Jump up ^ Turin L (June 2002). "A method for the calculation of odor character from molecular structure". Journal of Theoretical Biology 216 (3): 367–85. doi:10.1006/jtbi.2001.2504. PMID 12183125. Jump up ^ Keller A, Vosshall LB (April 2004). "A psychophysical test of the vibration theory of olfaction". Nature Neuroscience 7 (4): 337–8. doi:10.1038/nn1215. PMID 15034588. See also the editorial on p. 315. Jump up ^ Doty, R. L. (2001). Olfaction. 425. Retrieved from http://journals2.scholarsportal.info.myaccess.library.utoronto.ca/tmp/9139085232678633444.pdf Jump up ^ Bear, Connors and Paradiso, Mark, Barry and Michael (2007) Jump up ^ Morris, H., & Schaeffer, J. P. (1953). The Nervous system-The Brain or Encephalon. Human anatomy; a complete systematic treatise. (11th ed., pp.1218-1219). New York: Blakiston. Jump up ^ Margot C (July 2009). "A noseful of objects". Nat. Neurosci. 12 (7): 813–4. doi:10.1038/nn0709-813. PMID 19554043. Jump up ^ Zhou W, Chen D (2009). "Binaral rivalry between the nostrils and in the cortex". Curr Biol 19 (18): 1561–5. doi:10.1016/j.cub.2009.07.052. PMC 2901510. PMID 19699095. Jump up ^ Boehm T, Zufall F (February 2006). "MHC peptides and the sensory evaluation of genotype". Trends in neurosciences 29 (2): 100–7. doi:10.1016/j.tins.2005.11.006. PMID 16337283. Jump up ^ Porter RH, Cernoch JM, Balogh RD (1985). "Odor signatures and kin recognition". Physiol Behav 34 (3): 445–8. doi:10.1016/0031-9384(85)90210-0. PMID 4011726. Jump up ^ Lundström JN, Boyle JA, Zatorre RJ, Jones-Gotman M (August 2009). "The neuronal substrates of human olfactory based kin recognition". Human Brain Mapping 30 (8): 2571–80. doi:10.1002/hbm.20686. PMID 19067327. Jump up ^ Wilson DA (June 2001). "Receptive fields in the rat piriform cortex.". Chemical senses 26 (5): 577–84. PMID 11418503. ^ Jump up to: a b c d e Leon M., Johnson B.A. (2003). "Olfactory coding in the mammalian olfactory bulb". Brain Res. Brain Res. Rev. 42 (1): 23–32. doi:10.1016/S0165-0173(03)00142-5. PMID 12668289. Jump up ^ Howgego, J. (2013) Sense for scents traced down to genes. Nature News, 1 Aug 2013 Jump up ^ Jaeger, S Jump up ^ Masaoka Y, Satoh H, Akai L, Homma I (2010). "Expiration: The moment we experience retronasal olfaction in flavor". Neurosci Lett. 473 (2): 92–96. doi:10.1016/j.neulet.2010.02.024. PMID 20171264. Jump up ^ Annual Review of Psychology (February 2001), 52 (1), pg. 423-452,Richard L. Doty Jump up ^ Wesson D.W., Wilson D.A Jump up ^ Hirsch, Alan R. (2003) Life 's a Smelling Success Jump up ^ Gilbert, Avery (2008) Jump up ^ Fountain, Henry (3 October 2006). "This Plant Has the Sense of Smell (Loves Tomatoes, Hates Wheat)". The New York Times. Further reading Gordon M.s Shepherd Neurogastronomy: How the Brain Creates Flavor and Why It Matters New York : Columbia University Press, 2012 ISBN 978-0-231-15910-4

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