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Genetic Disorder Assignment: Colon Cancer

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Genetic Disorder Assignment: Colon Cancer
Biology March 15, 2013
Genetic Disorder Assignment (Colon Cancer)

Cancer is when cells divide only when they are needed to keep our bodies functioning properly; the mechanisms that regulate cell growth stop working and cells divide out of control to form tumors. When cancer develops in the cells lining the colon in the first part of the large intestine, it’s called Colon cancer. FAP (familial adenomatous polyposis) and HNPCC (hereditary non-polyposis colon cancer) are inherited in autosomal dominant pattern. If a parent has FAP or HNPCC, their children have a 50 percent chance of inheriting the mutated gene. However, the APC gene strikingly predisposes one to colon cancer. People who inherit one bad copy of the APC gene are practically
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Common symptoms are change in bowel habits (frequency, quality and consistency of stools) Bloody stools or rectal bleeding, Stools with mucus, Tarry stools, Feeling of incomplete defecation diarrhea or constipation, vomiting, bloating, cramps, and unexplained weight loss. Colon cancer is treatable. About 90 percent of patients survive the disease after the treatment. The first thing that doctors use in this stage the disease to see how far it has progressed. If the cancer has not spread to the other tissues of the body, it can be treated with radiation, special chemicals (chemotherapy) or surgery that will remove the polyps and cancerous part of the colon.

The patient should be aware of pain in the lower liver in the early stages diagnosed with the disease. It won’t be pleasant, and if any symptoms occur more than usually you should see your doctor for further more notice. Keeping a Healthy digestive system and eating onions can slice the risk of colon cancer in half. Having a good diet, healthy weight, getting the right amount of exercise, and eating fruits, vegetables, and whole grains are all things you can do to prevent Colon cancer. Stop smoking and If over 40 starts taking one aspirin a day. It protects your cells from becoming cancerous in many

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    According to Half, Brocovich, and Rozen (2009), more than 300 different types of mutations are recognized today as the cause of FAP. The mutations range from insertions, deletions, nonsense, and even repeats, which ultimately can result in a nonfunctional protein. The APC gene produces a protein known as the APC protein that is involved in regulating cell adhesion, signal transductions, and transcription activation. Park and Vogelstein (2003) stated that, “the localization of the APC protein is in the basolateral membrane of the colonic epithelial cells…” When mutations occur within this specific gene, it causes excessive proliferation of the colonic epithelial cells, which result in the formation of polyps and eventually tumors throughout the colon. There are certain medications that are provided for patients with this genetic disease, but they are simply given to treat and reduce the number and size of polyps. The prognosis for an individual with Familial Adenomatous Polyposis is that they will eventually have to undergo surgery to prevent colorectal cancer and malignant tumors from…

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