Fecal Transplant Case Study
Q1A: What is a fecal transplant (also called a fecal microbiome transplant, or a poop transplant)? Fecal transplant is to obtain fecal, or poop, sample, mix it with saline, and place it in patients. This treatment is used to treat clostridium difficile infection which is caused invasion of an anaerobic, gram-negative, spore-forming bacteria. This invasion is due to the treatment of antibiotics. When a patient acquires antibiotics, all the good bacteria is suppressed, and the purpose of fecal transplant is to replace the bad bacteria with good bacteria (The Fecal Transplant Foundation).
Q1B: Find three recent scientific studies (published in 2013 or later) that provide evidence for or against fecal transplant as an effective therapy for C. …show more content…
For Patient 1, before the treatment, she had 6 times reoccurrences of CDI over 18 months. Before CDI, she went into her knee surgery and was administered cefazolin. This caused her first CDI. After the fecal transplant treatment, her bowel cycle was normal and C. difficile was not detected in her stool sample 10 days after the treatment. Because of her urinary problems, she was administered to additional antibiotics; however, no sign of CDI occurred. For Patient 2, because she had cellulitis, she was administered cefazolin and had 3 times of reoccurrences of CDI. After the treatment, she bowel movement normalized. She was prescribed to ceftriaxone for her cellulitis after the treatment and still remained symptom-free because her bowel movement and stool were normal. Both stool samples from the patients contained ribotype 078 preceding the …show more content…
For this question, I want you to search ClinicalTrials.gov and find a study where fecal transplantation is being evaluated for treatment of a condition other than C. difficile infection. In your answer, include the following: (4 points)
1. A link to the clinical trial entry on clinicaltrials.gov https://clinicaltrials.gov/ct2/show/NCT02516384?term=fecal+transplantation&rank=5 2. What disease or condition is being treated?
Fecal transplant is used to treat inflammatory bowel disease which is a disease caused by dysfunctional gastrointestinal immune system.
Q5B: This is an opinion question. Would you be willing to try a fecal transplant as an alternative to antibiotic therapy, if you had a C. difficile infection? Why or why not? I would try fecal transplant because it is effective in treating C. difficile proven by the study with two patients. This treatment results in symptom-free and regulates bowel movement. Furthermore, fecal transplant lead to stably colonization of the good bacteria in human gastrointestinal tract which indicates that this treatment cures C. difficile
Q1B: Find three recent scientific studies (published in 2013 or later) that provide evidence for or against fecal transplant as an effective therapy for C. …show more content…
For Patient 1, before the treatment, she had 6 times reoccurrences of CDI over 18 months. Before CDI, she went into her knee surgery and was administered cefazolin. This caused her first CDI. After the fecal transplant treatment, her bowel cycle was normal and C. difficile was not detected in her stool sample 10 days after the treatment. Because of her urinary problems, she was administered to additional antibiotics; however, no sign of CDI occurred. For Patient 2, because she had cellulitis, she was administered cefazolin and had 3 times of reoccurrences of CDI. After the treatment, she bowel movement normalized. She was prescribed to ceftriaxone for her cellulitis after the treatment and still remained symptom-free because her bowel movement and stool were normal. Both stool samples from the patients contained ribotype 078 preceding the …show more content…
For this question, I want you to search ClinicalTrials.gov and find a study where fecal transplantation is being evaluated for treatment of a condition other than C. difficile infection. In your answer, include the following: (4 points)
1. A link to the clinical trial entry on clinicaltrials.gov https://clinicaltrials.gov/ct2/show/NCT02516384?term=fecal+transplantation&rank=5 2. What disease or condition is being treated?
Fecal transplant is used to treat inflammatory bowel disease which is a disease caused by dysfunctional gastrointestinal immune system.
Q5B: This is an opinion question. Would you be willing to try a fecal transplant as an alternative to antibiotic therapy, if you had a C. difficile infection? Why or why not? I would try fecal transplant because it is effective in treating C. difficile proven by the study with two patients. This treatment results in symptom-free and regulates bowel movement. Furthermore, fecal transplant lead to stably colonization of the good bacteria in human gastrointestinal tract which indicates that this treatment cures C. difficile