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Stem Cell Transplantation

Allogeneic stem cell transplantation after reduced intensity conditioning in patients with relapsed or refractory Hodgkin’s lymphoma. Results of the HDR-ALLO study – a prospective clinical trial by the Grupo Español de Linfomas/ Trasplante de Médula Osea (GEL/TAMO) and the Lymphoma Working Party of the European Group for Blood and Marrow Transplantation
Anna Sureda,1,2 Carme Canals,3 Reyes Arranz,4 Dolores Caballero,5 Josep Maria Ribera,6 Mats Brune,7 Jacob Passweg,8 Rodrigo Martino,1 David Valcárcel,1 Joan Besalduch,9 Rafael Duarte,10 Angel León,11 Maria Jesus Pascual,12 Ana García-Noblejas,4 Lucia López Corral,5 Bianca Xicoy,6 Jordi Sierra,1 and Norbert Schmitz13
1 Hematology Department, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain; 2Department of Haematology, Addenbrooke’s Hospital, Cambridge, UK; 3EBMT Office, Barcelona, Spain; 4Hematology Department, Hospital de la Princesa, Madrid, Spain; 5 Hematology Department, Hospital Clínico Universitario, Salamanca, Spain; 6Hematology Department, ICO-Hospital Germans Trias i Pujol, Badalona, Spain; 7Hematology Section, Sahlgrenska University Hospital, Göteborg, Sweden; 8Departement Medecine Interne, Hopitaux Universitaires de Geneve, Geneve, Switzerland; 9Hematology Department, Hospital Son Dureta, Palma de Mallorca, Spain; 10Institut Català d’Oncologia, L’Hospitalet de Llobregat, Spain; 11Hematology Department, Hospital de Jerez de la Frontera, Jerez de la Frontera, Spain; 12Hematology Department, Hospital Carlos Haya, Málaga, Spain, and 13 Hematology/Oncology Department, Asklepios Klinik St. Georg, Hamburg, Germany

ABSTRACT Background
Although Hodgkin’s lymphoma is a highly curable disease with modern chemotherapy protocols, some patients are primary refractory or relapse after first-line chemotherapy or even after high-dose therapy and autologous stem cell transplantation. We investigated the potential role of allogeneic stem cell


References: py compared with COPP-ABVD for advanced Hodgkin’s disease. N Engl J Med. 2003;348(24):2386-95. 3. Linch DC, Winfield D, Goldstone AH, Moir D, Hancock B, McMillan A, et al. Dose intensification with autologous bone-mar- 316
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