Effects Of PRL On Nscs
Effects of PRL on NSCs/NPCs
Like other stem cells, NSCs have the capacities of proliferation and multipotent differentiation. Studies have shown that NSCs can be induced into various neural component cells in vitro, such as astrocytes, oligodendrocytes and neurons [45]. NPCs are capable to divide only a limited number of times and differentiate into a specific type of neuronal cells [46]. The subgranular zone (SGZ), locating between the granule cell layer and hilus of the hippocampus dentate gyrus, consists of several cell types, including NSCs, the most prominent one, and other cells such as astrocytes and endothelial cells. The NSCs in SGZ generate only one type of neurons, the granule cells, which are the primary excitatory neurons in the
Like other stem cells, NSCs have the capacities of proliferation and multipotent differentiation. Studies have shown that NSCs can be induced into various neural component cells in vitro, such as astrocytes, oligodendrocytes and neurons [45]. NPCs are capable to divide only a limited number of times and differentiate into a specific type of neuronal cells [46]. The subgranular zone (SGZ), locating between the granule cell layer and hilus of the hippocampus dentate gyrus, consists of several cell types, including NSCs, the most prominent one, and other cells such as astrocytes and endothelial cells. The NSCs in SGZ generate only one type of neurons, the granule cells, which are the primary excitatory neurons in the