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Effect of Vitamin E and Selenium as Immunomodulators on Induced Aflatoxicosis in Broiler Birds

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Effect of Vitamin E and Selenium as Immunomodulators on Induced Aflatoxicosis in Broiler Birds
Pak. j. life soc. sci. (2009), 7(1):31-34

Pakistan Journal of Life and Social Sciences

Effect of Vitamin E and Selenium as Immunomodulators on Induced Aflatoxicosis in Broiler Birds
Ab eer a M ub ar a k, As i f R as h id , I mt ia z Ah mad K h an a nd Az har H u ss ai n Vet eri n ar y Re sea r c h I n s tit u te, G ha zi Ro ad La ho re Ca nt t -P a ki s ta n Abstract Mycotoxicosis, a serious problem to commercial poultry, is incurable; however certain group B vitamins, vitamin E and selenium are capable of reducing and facilitating the decomposition and detoxification of mycotoxin within the body. In present study, effect of vitamin E and selenium was studied in broiler birds with induced aflatoxicosis. Five groups of broilers birds were reared and feed differently i.e., Group B was fed with vitamin E and selenium along with aflatoxin B1 mixed feed, group C was fed with vitamin E and aflatoxin B1 mixed feed, group D was fed with selenium and aflatoxin B1 mixed feed and group E was fed only aflatoxin B1 mixed feed while group A was kept as control. The study was conducted for three weeks and concluded that vitamin E and selenium in combination can act as immunomodulator even then the birds were challenged with aflatoxin B1. Keywords: Mycotoxicosis, vitamin E, selenium immunmodulator Introduction Mycotoxins are the metabolic products of toxigenic fungi, released during the growth in various feedstuffs. Aflatoxins are the most common mycotoxins, widely prevalent in different feed commodities. These toxins are considered to be most important because of wide range of host susceptibility, immunosuppression, hepatotoxicity and heat stable properties of aflatoxin and are potential hazards affecting the poultry industry resulting in heavy economic losses (Mundas and Rao, 2001). Aflatoxins are proved to suppress the immune response of the birds leading to persistence of Newcastle disease in broiler flock even after vaccination (Mani et al., 2001). Various findings



References: Afzal, M, and Z. Saleem, Effect of addition of a mycotoxin detoxifier in poultry feed containing different levels of aflatoxins on the performance of broilers. AsianAustralian J. of Ani. Sci., 2004. 17. 990-994. Anonymous., Official method of analysis. 14th Ed. Association of official analytical chemists. Arrington, Virginia. U.S.A. 1990. Balker, S., Role of vitamin E in enhancing in immune response. Proceeding of 2nd Asian /Pacific poultry health, Australia. 1993. Brugh, M., 1997. A simple method for recording and analyzing serological data. Avian Dis., 22:362-365. Gupta, K., and S. Amarjit, Experimental studies on aflatoxicosis, infectious bursal disease and their interaction in broiler chicks. Ind. J. Vet. Pathology., 2003. 27:5-7. Flora, P., and J. Malathy, Effect of aflatoxin B7 on phosphorous, alkaline phosphate and some haematological parameters on white leghorn breed (Gallus gallus domesticus). Toxi. Int., II 2004. 1: 33-41. Mani, K., K. Sundaresan, and K. Viswanathan, Effect of immunomodulators on the performance of broilers in aflatoxicosis. Ind. Vet. J., 2001. 78: 1126-1129. Mundas, S., and D. G. K. Rao, Histological changes in liver by aflatoxin and fanvelerate treated broiler birds. Ind. Vet. J., 2001.78:11521153. Nataraja, T. H., H. D. N. Swam, S. K. Vijayasarathi, B. S. Kumar, and G. C. Prakash,. Pathology of lymphoid organs of broiler chickens with aflatoxicosis and T-2 toxicosis. Ind. J. Ani. Sci ., 2003.73:1342-1343. Perozo, F and S. Rivera, Effect of aflatoxin B1 exposure and selenium supplementation on immune response in broilers. Ind. Vet. J., 2003. 80 : 1218-1221. Prakash, G. C., T. S. Nalini, S. K Vijayasarathi, and B. Umakantha, Pathomorphological studies to evaluate the effect of combination of aflatoxin and ochratoxin in broiler chickens. Ind. J. Ani. Sci., 2002. 72: 418-420. Shivachandra, S. B., R. L. Sah, S. D. Singh, T. S Johri, and K. Manimaran, Pathobiochemical and immunological changes in experimental aflatoxicosis. Ind. J. Poultry Sci., 2003. 38.:137-141. 33 Mubarak et al Srivani, M., Y. Anjaneyulu, A. S. Rao, B. J. R. Sarma, and M. V. L. N. Raju, Efficacy of Immunomodulators on induced aflatoxicosis in broiler chicks - a pathological study. Ind. J. Vet. Path., 2003. 27:27-29. Steel, R. G. D., J. H. Torrie, and D. Dickey, Principles and Procedures of Statistics. A Biometrical Approach, 3rd Ed. McGraw Hill Book Co New York, USA. 1997. 34

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