Dexmedetomidine In Burn Patients: A Literature Review
Analgesic and Sedative Effects of Dexmedetomidine in Burn Patients:
A Literature Review
It is a well-documented fact that patients with severe burn injuries experience continuous blood loss in the treatment process. With major burn injuries, patients may experience acute anemia, which occurs primarily from the surgical administration of the burn wound, anemia of critical illness, and iatrogenic blood loss. Burn patients may experience repeated painful techniques like dressing changes, which require general anesthesia or analgosedation depending on location, size, and origin of the wound defect. Institutional preferences largely determine the choice of drugs and techniques for analgosedation in burn patients. The researchers and clinicians have demonstrated the need for more profound and better sedation, as well as for prevention of hypertension when utilizing dexmedetomidine as an adjunct during burn procedures. Dexmedetomidine, a selective a2-adrenergic agonist, is used in anesthetic practice because of its combined analgesic, sedative, hypnotic and …show more content…
However, none of the studies showed the confidence interval in their statistical analysis, which is crucial to assess the study quality. The authors suggest that additional prospective, randomized, controlled multicenter trials with a sufficient number of patients is needed to further clarify the potentially helpful effects of dexmedetomidine for administration in the care of burn patients. Furthermore, the study must be standardized for administration and dosages. The perioperative period should be focused on the assessment of sedation, analgesia, and hemodynamics changes. The half-life of the medications utilized must be taken into account and reiteration of doses should be considered to examine the drug profile of dexmedetomidine in burn
A Literature Review
It is a well-documented fact that patients with severe burn injuries experience continuous blood loss in the treatment process. With major burn injuries, patients may experience acute anemia, which occurs primarily from the surgical administration of the burn wound, anemia of critical illness, and iatrogenic blood loss. Burn patients may experience repeated painful techniques like dressing changes, which require general anesthesia or analgosedation depending on location, size, and origin of the wound defect. Institutional preferences largely determine the choice of drugs and techniques for analgosedation in burn patients. The researchers and clinicians have demonstrated the need for more profound and better sedation, as well as for prevention of hypertension when utilizing dexmedetomidine as an adjunct during burn procedures. Dexmedetomidine, a selective a2-adrenergic agonist, is used in anesthetic practice because of its combined analgesic, sedative, hypnotic and …show more content…
However, none of the studies showed the confidence interval in their statistical analysis, which is crucial to assess the study quality. The authors suggest that additional prospective, randomized, controlled multicenter trials with a sufficient number of patients is needed to further clarify the potentially helpful effects of dexmedetomidine for administration in the care of burn patients. Furthermore, the study must be standardized for administration and dosages. The perioperative period should be focused on the assessment of sedation, analgesia, and hemodynamics changes. The half-life of the medications utilized must be taken into account and reiteration of doses should be considered to examine the drug profile of dexmedetomidine in burn