case study in Iran ABO and breast cancer
The following case-control study took place in Arak, Iran that involves ABO blood groups and prognosis of breast cancer. The purpose of this study is to evaluate the coloration between ABO blood groups and the prognosis of breast cancer and the subjects for this controlled study was in Arak city, Arak, Iran. One hundred and thirty four patients with breast cancer were included in the study and their blood types were taken from their medical record. Analysis show that tumors come in different sizes. Breast cancer is defined as the most frequent malignant tumor, accounting for 30 percent of all malignancies and the second cause of mortality due to cancer among females. The mortality of this cancer mostly occurs in the peak of familial, social and economic activities in (35 – 45 years of age). The incidence of breast cancer 1 per 7 women. However, there are couple of factors that play a role in the incidence genetics, hormones, lactation, late menopause, diet, radiation, alcohol consumption, and exogenous estrogen intake. On the other side, the tumor size, estrogen and progesterone receptor status and levels, tumor histology and the speed of cellular proliferation are some factors which affect the prognosis.4,5 If the disease has poor prognosis, various invasive therapeutic methods will be used to treat patients. The blood group type is one of the genetic factors which affect the risk of different cancers. Studies of associations between tumors outcome and the patients’ ABO blood groups have shown increased relative risks for some of blood groups. The A type is more frequent in patients with larynx and hypo pharynx tumors, acute myeloblastic leukemia, ovarian, pancreas, breast, vulvar and gastric malignancies. A positive association with O type has been reported with several tumors like the squamous cell carcinoma of the esophagus, gastric cancer, acute lymphoblastic leukemia and skin melanoma. Few other differences have been described for other blood groups namely