Acetaminophen Synthesis Lab Report
Experiment 1
Synthesis of Acetaminophen
Clifford Tse
20529845
Partner – Raminder Dhanoa
TA – Xiao Qi
CHEM 123L - 012
February 6, 2014
Introduction
Acetaminophen, also commonly known as Tylenol, is an over-the-counter medicine used to relieve pain and reduce fevers. Within this experiment, Acetaminophen will be formed through the reaction between p-aminophenol and acetic anhydride. This reaction will incur Acetaminophen as a crude solid being impure, which will be purified further through the use of a recrystallization technique. The purification process involves dissolving a solid and recrystallizing as a crystal solid from the solution. The process is follow by heating the crude solid to dissolve using a minimal amount of solvent, …show more content…
In this experiment, each 10 mL of water was added for every 1 g of crude product produced. This is due to the solution retaining its saturated state, where 10mL per 1 g of crude is the correct ratio to sustain the solution. If 5 mL of water were to be added as the ratio instead, the solution would become supersaturated, resulting in having an effect to the recrystallization process.
b. If 15 mL of water was added for every 1 g of crude product, the solution would become unsaturated. There would be an excess amount of water within the ratio thus affects the purity of the product since more of the crude product would be required.
c. If the room temperature was used rather than a cold solvent in aiding the transfer of recrystallized products, the solubility of the crystals would be higher, thus incurring a possible loss in crystals during the vacuum filtration process. This in turn, would result in a loss of yield and ultimately affects the overall yield calculations.
d. The purpose of scratching the inner walls of the round bottom flask is to initiate the recrystallization process through the crystal growth stage.
2. Within the field of chemistry, the definition of an organic compound is a compound that contains carbon (Petrucci, et al.,
Synthesis of Acetaminophen
Clifford Tse
20529845
Partner – Raminder Dhanoa
TA – Xiao Qi
CHEM 123L - 012
February 6, 2014
Introduction
Acetaminophen, also commonly known as Tylenol, is an over-the-counter medicine used to relieve pain and reduce fevers. Within this experiment, Acetaminophen will be formed through the reaction between p-aminophenol and acetic anhydride. This reaction will incur Acetaminophen as a crude solid being impure, which will be purified further through the use of a recrystallization technique. The purification process involves dissolving a solid and recrystallizing as a crystal solid from the solution. The process is follow by heating the crude solid to dissolve using a minimal amount of solvent, …show more content…
In this experiment, each 10 mL of water was added for every 1 g of crude product produced. This is due to the solution retaining its saturated state, where 10mL per 1 g of crude is the correct ratio to sustain the solution. If 5 mL of water were to be added as the ratio instead, the solution would become supersaturated, resulting in having an effect to the recrystallization process.
b. If 15 mL of water was added for every 1 g of crude product, the solution would become unsaturated. There would be an excess amount of water within the ratio thus affects the purity of the product since more of the crude product would be required.
c. If the room temperature was used rather than a cold solvent in aiding the transfer of recrystallized products, the solubility of the crystals would be higher, thus incurring a possible loss in crystals during the vacuum filtration process. This in turn, would result in a loss of yield and ultimately affects the overall yield calculations.
d. The purpose of scratching the inner walls of the round bottom flask is to initiate the recrystallization process through the crystal growth stage.
2. Within the field of chemistry, the definition of an organic compound is a compound that contains carbon (Petrucci, et al.,