5 Alpha Reductase Inhibitor Research Paper
5-alpha reductase inhibitors. The medications in this category shrink prostate by preventing hormonal changes that cause prostate growth. The mechanism of action is that 5-alpha reductase inhibitor medication blocks the conversion of testosterone to DHT resulting in lower intraprostatic levels of DHT. This process causes change in epithelial cell of the transition zone. This process leads to inhibition of prostatic growth, involution, and apoptosis. Eventually, prostate volume and progression of disease will be decreased. Thus, patients with larger prostates may achieve a greater benefit. However, maximal reduction in prostate volume requires 6 months of therapy. These medications include Finasteride (Proscar) and Dutasteride. Side effects