4-Ylmethylethylation Lab Report
Results and Discussion: A reaction involving two bond formation was employed for the preparation of 3,5-disubstituted 1,2,4-triazole as nucleobase analog. The hydrazides 2a,b were allowed to react with the heteroaryl substituted acetonitrile derivatives 1a-c using catalytic amount of K2CO3 and n-butanol as a solvent to afford the disubstituted 1,2,4-triazoles 3-7 bearing benzothiazole, benzotriazole, quinoloxymethyl and benziimidazole ring systems in moderate yields. The structures of compounds 3-7 were confirmed by their spectral data. Their IR spectra revealed the disappearance of the characteristic hydrazide carbonyl and cyano absorption bands. The 1H NMR spectra showed signals corresponding to the two methylene protons in addition to the aryl and NH proton of the 1,2,4-triazole ring.
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The Infra-Red spectra showed the carbonyl of the acetyl groups in addition to the disappearance of the NH band. Their 1H NMR spectra showed the acetyl methyl signals, the sugar protons signals and the aromatic signals. The coupling constant value of the anomeric protons 9.8-10.2 Hz indicated that attachment of the sugar moiety is in the beta conformation leading to the formation of the
The Infra-Red spectra showed the carbonyl of the acetyl groups in addition to the disappearance of the NH band. Their 1H NMR spectra showed the acetyl methyl signals, the sugar protons signals and the aromatic signals. The coupling constant value of the anomeric protons 9.8-10.2 Hz indicated that attachment of the sugar moiety is in the beta conformation leading to the formation of the